Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, People's Republic of China.
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, People's Republic of China.
J Nat Prod. 2020 Jun 26;83(6):1998-2003. doi: 10.1021/acs.jnatprod.0c00189. Epub 2020 Jun 3.
A new dihydrobenzofuran-phenyl acrylate hybrid, aspeterreurone A (), was obtained from the culture of the deep-sea-derived fungus CC-S06-18. The relative configuration of was elucidated by HSQMBC NMR, calculated NMR chemical shifts coupled with a statistical procedure (DP4+), and the absolute configuration was established by ECD calculations. exhibited cytotoxicities against the gastric cancer cell lines HGC27, MGC803, BGC823, and AGS, with minimal effects on normal gastric epithelial cell line GES-1. Further studies showed that inhibited cell cycle progression and induced apoptosis of gastric cancer MGC803 cells in a concentration-dependent manner. Western blot analysis indicated that inhibited the phosphorylation of STAT3, which might contribute to its cytotoxic activity.
一种新的二氢苯并呋喃-苯丙烯酸酯杂合体，aspeterreurone A ()，是从深海来源的真菌 CC-S06-18 的培养物中获得的。通过 HSQMBC NMR、计算 NMR 化学位移与统计程序 (DP4+) 的结合，阐明了的相对构型，通过 ECD 计算确定了绝对构型。表现出对胃癌细胞系 HGC27、MGC803、BGC823 和 AGS 的细胞毒性，对正常胃上皮细胞系 GES-1 的影响最小。进一步的研究表明，以浓度依赖的方式抑制胃癌 MGC803 细胞的细胞周期进程并诱导细胞凋亡。Western blot 分析表明，抑制了 STAT3 的磷酸化，这可能有助于其细胞毒性活性。
