从海洋来源真菌 DSW-2 中分离得到的新型环三肽的结构解析。

Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus DSW-2.

机构信息

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.

Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, Xiamen, China.

出版信息

Nat Prod Res. 2022 Jul;36(14):3572-3578. doi: 10.1080/14786419.2020.1869969. Epub 2021 Jan 4.

DOI:10.1080/14786419.2020.1869969

PMID:33397147

Abstract

A novel cyclic tripeptide, sclerotiotide M (), was isolated from the culture of a marine derived fungus DSW-2, together with four known compounds (-). The planar structure of was established by 1 D and 2 D NMR data, supported by mass spectrometry, and the relative configuration was established by calculated NMR chemical shifts coupled with a statistical method (DP4+). All the compounds (-) displayed weak cytotoxic activities against cancer cell lines HPAC and BXPC3, with IC values over 20 μM.

摘要

一种新型环三肽 sclerotiotide M () 从海洋来源真菌 DSW-2 的培养物中分离得到，同时还分离得到了四个已知化合物 (-)。化合物的平面结构通过 1D 和 2D NMR 数据、质谱以及计算 NMR 化学位移与统计方法 (DP4+) 确定的相对构型来建立。所有化合物 (-) 对 HPAC 和 BXPC3 癌细胞系表现出较弱的细胞毒性，IC 值均超过 20 μM。