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检测DNA（8-羟基脱氧鸟苷）作为镍对镍铬合金假体使用者影响的毒性生物指标。

Detection of DNA (8-OHdG) as a toxicity bioindicator to the effects of nickel on Ni-Cr alloy prosthesis users.

作者信息

Utari Dian Retno, Auerkari Elza Ibrahim

机构信息

Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia.

出版信息

Saudi J Biol Sci. 2020 Jun;27(6):1643-1648. doi: 10.1016/j.sjbs.2020.03.006. Epub 2020 Mar 12.

DOI:10.1016/j.sjbs.2020.03.006
PMID:32489306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7253878/
Abstract

Previous studies have suggested that exposure to Ni from Ni-Cr alloys can affect the human body through oxidative stress. The present study discusses the effect of nickel from Ni-Cr alloy prostheses on the formation of DNA Adduct 8-Hydroxy-2'-Deoxyguanosine (8-OHdG), evaluated based on creatinine and 8-OHdG concentrations in urine, determined with LC-MS/MS, for a Ni-Cr alloy user group and a never-user control group. The mean creatinine and 8-OHdG concentrations were not significantly different between the test groups, although highest levels were observed for the in the Ni-Cr user group. It is suggested that samples with relatively high creatinine and/or 8-OHdG levels are further studied in more detail for stability of concentrations and for the effect of contributing factors.

摘要

以往的研究表明，接触镍铬合金中的镍会通过氧化应激影响人体。本研究探讨了镍铬合金假体中的镍对DNA加合物8-羟基-2'-脱氧鸟苷（8-OHdG）形成的影响，通过液相色谱-串联质谱法测定镍铬合金使用者组和非使用者对照组尿液中的肌酐和8-OHdG浓度来进行评估。尽管在镍铬使用者组中观察到最高水平，但测试组之间的平均肌酐和8-OHdG浓度没有显著差异。建议对肌酐和/或8-OHdG水平相对较高的样本进一步详细研究其浓度稳定性和影响因素的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/20ff61d4e0f8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/9b9721819142/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/6789e606377e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/4bb9d818d7e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/79982f28f3a2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/20ff61d4e0f8/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/9b9721819142/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/6789e606377e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/4bb9d818d7e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/79982f28f3a2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32c2/7253878/20ff61d4e0f8/gr5.jpg

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