• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与接受生活方式疾病治疗的动脉粥样硬化性心血管疾病相关的反应性充血指数

Reactive Hyperemia Index Associated With Atherosclerotic Cardiovascular Disease Under Treatment for Lifestyle Diseases.

作者信息

Motozato Kota, Suematsu Yasunori, Norimatsu Kenji, Kusumoto Takaaki, Miura Shin-Ichiro

机构信息

Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

Department of Cardiology, Izumi General Medical Center, Kagoshima, Japan.

出版信息

J Clin Med Res. 2020 May;12(5):293-299. doi: 10.14740/jocmr4100. Epub 2020 May 8.

DOI:10.14740/jocmr4100
PMID:32489504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7239580/
Abstract

BACKGROUND

Endothelial dysfunction is an early phase of atherosclerosis and causes atherosclerotic cardiovascular disease (ASCVD), but the cutoff reactive hyperemia index (RHI) for identifying ASCVD patients under treatment for lifestyle diseases is unknown.

METHODS

Patients who visited Cardiology Section, Izumi General Medical Center, Kagoshima, Japan and were measured RHI using Endo-PAT 2000 during May 2014 and March 2016 were enrolled. We divided them into ASCVD and non-ASCVD groups and investigated the association with RHI between the groups.

RESULTS

ASCVD group included 195 patients and non-ASCVD group included 288 patients. Age, body mass index and the rate of male, hypertension, diabetes, dyslipidemia and chronic kidney disease in the ASCVD group were significantly higher than those in non-ASCVD group. RHI in the ASCVD group (1.65 (1.40 - 1.92)) was significantly lower than that in the non-ASCVD group (1.73 (1.45 - 2.24)) (P < 0.05). In multi-regression analysis, RHI (odds ratio: 0.67, 95% confidence interval: 0.45 - 0.99, P = 0.04) was independently associated with ASCVD after adjusted by age, sex, body mass index, smoking, hypertension, diabetes, dyslipidemia and chronic kidney disease. The cutoff RHI value between the groups was 1.80.

CONCLUSION

RHI was significantly associated with ASCVD under treatment for lifestyle diseases and the cutoff value was 1.80.

摘要

背景

内皮功能障碍是动脉粥样硬化的早期阶段，可导致动脉粥样硬化性心血管疾病（ASCVD），但用于识别接受生活方式疾病治疗的ASCVD患者的反应性充血指数（RHI）临界值尚不清楚。

方法

纳入2014年5月至2016年3月期间就诊于日本鹿儿岛和泉综合医疗中心心内科并使用Endo-PAT 2000测量RHI的患者。我们将他们分为ASCVD组和非ASCVD组，并研究两组之间RHI的相关性。

结果

ASCVD组包括195例患者，非ASCVD组包括288例患者。ASCVD组的年龄、体重指数、男性比例、高血压、糖尿病、血脂异常和慢性肾脏病的发生率均显著高于非ASCVD组。ASCVD组的RHI（1.65（1.40 - 1.92））显著低于非ASCVD组（1.73（1.45 - 2.24））（P < 0.05）。在多因素回归分析中，经年龄、性别、体重指数、吸烟、高血压、糖尿病、血脂异常和慢性肾脏病校正后，RHI（比值比：0.67，95%置信区间：0.45 - 0.99，P = 0.04）与ASCVD独立相关。两组之间的RHI临界值为1.80。

结论

RHI与接受生活方式疾病治疗的ASCVD显著相关，临界值为1.80。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/72f7830c386a/jocmr-12-293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/7d75d60510df/jocmr-12-293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/e6b2af0d875d/jocmr-12-293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/72f7830c386a/jocmr-12-293-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/7d75d60510df/jocmr-12-293-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/e6b2af0d875d/jocmr-12-293-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fab/7239580/72f7830c386a/jocmr-12-293-g003.jpg

相似文献

1
Reactive Hyperemia Index Associated With Atherosclerotic Cardiovascular Disease Under Treatment for Lifestyle Diseases.与接受生活方式疾病治疗的动脉粥样硬化性心血管疾病相关的反应性充血指数
J Clin Med Res. 2020 May;12(5):293-299. doi: 10.14740/jocmr4100. Epub 2020 May 8.
2
Endothelial function estimated by digital reactive hyperemia in patients with atherosclerotic risk factors or coronary artery disease.通过数字反应性充血评估有动脉粥样硬化危险因素或冠状动脉疾病患者的内皮功能。
Heart Vessels. 2018 Jul;33(7):706-712. doi: 10.1007/s00380-018-1118-4. Epub 2018 Jan 19.
3
Endothelial Dysfunction Is Associated with Cerebrovascular Events in Pre-Dialysis CKD Patients: A Prospective Study.内皮功能障碍与透析前慢性肾脏病患者的脑血管事件相关：一项前瞻性研究。
Life (Basel). 2021 Feb 7;11(2):128. doi: 10.3390/life11020128.
4
Association between lowered endothelial function measured by peripheral arterial tonometry and cardio-metabolic risk factors - a cross-sectional study of Finnish municipal workers at risk of diabetes and cardiovascular disease.外周动脉张力测定法评估的内皮功能降低与心血管代谢危险因素的相关性——一项芬兰有糖尿病和心血管疾病风险的市政工作人员的横断面研究。
BMC Cardiovasc Disord. 2013 Oct 11;13:83. doi: 10.1186/1471-2261-13-83.
5
The comparison of endothelial function between conduit artery and microvasculature in patients with coronary artery disease.冠心病患者的大血管和微血管内皮功能比较。
Cardiol J. 2020;27(1):38-46. doi: 10.5603/CJ.a2018.0077. Epub 2018 Aug 29.
6
Peripheral arterial endothelial dysfunction predicts future cardiovascular events in diabetic patients with albuminuria: a prospective cohort study.外周动脉内皮功能障碍可预测伴有蛋白尿的糖尿病患者的未来心血管事件：一项前瞻性队列研究。
Cardiovasc Diabetol. 2020 Jun 13;19(1):82. doi: 10.1186/s12933-020-01062-z.
7
Peripheral Reactive Hyperemia Index and Coronary Microvascular Function in Women With no Obstructive CAD: The iPOWER Study.无阻塞性 CAD 女性的外周反应性充血指数与冠状动脉微血管功能：iPOWER 研究。
JACC Cardiovasc Imaging. 2016 Apr;9(4):411-7. doi: 10.1016/j.jcmg.2016.02.005.
8
A Study of the Vascular Endothelial Function in Patients with Type 2 Diabetes Mellitus and Rheumatoid Arthritis.2型糖尿病合并类风湿关节炎患者血管内皮功能的研究
Intern Med. 2019;58(10):1383-1390. doi: 10.2169/internalmedicine.1564-18. Epub 2019 May 15.
9
Effects of the Mean Amplitude of Glycemic Excursions and Vascular Endothelial Dysfunction on Cardiovascular Events in Nondiabetic Patients With Coronary Artery Disease.血糖波动平均幅度及血管内皮功能障碍对非糖尿病冠心病患者心血管事件的影响
J Am Heart Assoc. 2017 Apr 26;6(5):e004841. doi: 10.1161/JAHA.116.004841.
10
Digital microvascular reactivity does not decline with impaired renal function in chronic kidney disease.慢性肾脏病患者肾功能受损时，微血管反应性并不降低。
BMC Nephrol. 2019 Jul 30;20(1):288. doi: 10.1186/s12882-019-1484-x.

引用本文的文献

1
Identification of differentially expressed miRNAs involved in vascular aging reveals pathways associated with the endocrine hormone regulation.参与血管衰老的差异表达miRNA的鉴定揭示了与内分泌激素调节相关的途径。
Biogerontology. 2024 Dec 7;26(1):23. doi: 10.1007/s10522-024-10167-x.
2
Protective effects of blueberries on vascular function: A narrative review of preclinical and clinical evidence.蓝莓对血管功能的保护作用：临床前和临床证据的叙述性综述。
Nutr Res. 2023 Dec;120:20-57. doi: 10.1016/j.nutres.2023.09.007. Epub 2023 Sep 28.
3
Impact of Blood-Flow-Restricted Training on Arterial Functions and Angiogenesis-A Systematic Review with Meta-Analysis.

本文引用的文献

1
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).日本高血压学会高血压管理指南（JSH 2019）。
Hypertens Res. 2019 Sep;42(9):1235-1481. doi: 10.1038/s41440-019-0284-9.
2
Physiological Diagnostic Criteria for Vascular Failure.血管衰竭的生理诊断标准。
Hypertension. 2018 Nov;72(5):1060-1071. doi: 10.1161/HYPERTENSIONAHA.118.11554.
3
The SGLT2 Inhibitor Dapagliflozin Significantly Improves the Peripheral Microvascular Endothelial Function in Patients with Uncontrolled Type 2 Diabetes Mellitus.
血流限制训练对动脉功能和血管生成的影响——一项荟萃分析的系统评价
Biomedicines. 2023 May 31;11(6):1601. doi: 10.3390/biomedicines11061601.
4
Generalized metabolic flux analysis framework provides mechanism-based predictions of ophthalmic complications in type 2 diabetes patients.广义代谢通量分析框架为2型糖尿病患者的眼科并发症提供基于机制的预测。
Health Inf Sci Syst. 2023 Mar 29;11(1):18. doi: 10.1007/s13755-023-00218-x. eCollection 2023 Dec.
5
Coronary endothelial dysfunction: from pathogenesis to clinical implications.冠状动脉内皮功能障碍：从发病机制到临床意义。
Open Heart. 2022 Dec;9(2). doi: 10.1136/openhrt-2022-002200.
6
Path analysis of the impact of prenatal alcohol on adult vascular function.产前酒精对成年血管功能影响的路径分析。
Alcohol Clin Exp Res (Hoboken). 2023 Jan;47(1):116-126. doi: 10.1111/acer.14970. Epub 2022 Nov 16.
7
Salivary Microbiota Associated with Peripheral Microvascular Endothelial Dysfunction.唾液微生物群与外周微血管内皮功能障碍相关。
J Atheroscler Thromb. 2023 Jul 1;30(7):820-833. doi: 10.5551/jat.63681. Epub 2022 Sep 22.
8
Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS).新冠后(post-COVID-19)综合征和慢性疲劳综合征（ME/CFS）患者的血管内皮功能障碍和内皮生物标志物改变。
J Transl Med. 2022 Mar 22;20(1):138. doi: 10.1186/s12967-022-03346-2.
9
Relationships between peripheral reactive hyperemia index with coronary plaque burden and prognosis in patients with unstable angina pectoris complicated with type 2 diabetes mellitus.不稳定型心绞痛合并2型糖尿病患者外周反应性充血指数与冠状动脉斑块负荷及预后的关系
Ann Transl Med. 2021 Apr;9(8):655. doi: 10.21037/atm-21-657.
钠-葡萄糖协同转运蛋白2抑制剂达格列净显著改善未控制的2型糖尿病患者的外周微血管内皮功能。
Intern Med. 2018 Aug 1;57(15):2147-2156. doi: 10.2169/internalmedicine.0701-17. Epub 2018 Mar 30.
4
Association of obstructive sleep apnea with microvascular endothelial dysfunction and subclinical coronary artery disease in a community-based population.社区人群中阻塞性睡眠呼吸暂停与微血管内皮功能障碍及亚临床冠状动脉疾病的相关性。
Vasc Med. 2018 Aug;23(4):331-339. doi: 10.1177/1358863X18755003. Epub 2018 Mar 14.
5
Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study.反应性充血指数 (RHI) 和认知表现指数与非酒精性脂肪性肝病 (NAFLD) 患者的肝脏疾病组织学标志物相关：一项病例对照研究。
Cardiovasc Diabetol. 2018 Feb 16;17(1):28. doi: 10.1186/s12933-018-0670-7.
6
Comparison of the effects of linagliptin and voglibose on endothelial function in patients with type 2 diabetes and coronary artery disease: a prospective, randomized, pilot study (EFFORT).利格列汀与伏格列波糖对2型糖尿病合并冠状动脉疾病患者内皮功能影响的比较：一项前瞻性、随机、试点研究（EFFORT）
Heart Vessels. 2018 Aug;33(8):958-964. doi: 10.1007/s00380-018-1136-2. Epub 2018 Feb 9.
7
Associations between microalbuminuria and parameters of flow-mediated vasodilatation obtained by continuous measurement approaches.连续测量方法获得的微量白蛋白尿与血流介导的血管扩张参数之间的关联。
Clin Exp Hypertens. 2018;40(8):715-720. doi: 10.1080/10641963.2018.1425422. Epub 2018 Jan 19.
8
2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断： 。
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27. doi: 10.2337/dc18-S002.
9
Effect of Aggressive lipid-lowering treatment with Rosuvastatin on vascular endoTHelium function: evaluation of vascular endothelium function (EARTH study).瑞舒伐他汀强化降脂治疗对血管内皮功能的影响：血管内皮功能评估（EARTH研究）
Heart Vessels. 2018 Jun;33(6):590-594. doi: 10.1007/s00380-017-1094-0. Epub 2017 Dec 5.
10
Reactive Hyperemia Index in Patients on Maintenance Hemodialysis: Cross-sectional Data from a Cohort Study.维持性血液透析患者的反应性充血指数：一项队列研究的横断面数据。
Sci Rep. 2017 Mar 30;7:45757. doi: 10.1038/srep45757.