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一名系统性红斑狼疮患儿的肺含铁血黄素沉着症:一种罕见的表现。

Pulmonary Hemosiderosis in a Child With Systemic Lupus Erythematosus: A Rare Presentation.

作者信息

Rajvanshi Nikhil, Chacham Swathi, Chegondi Madhuradhar, Goyal Jagdish P, Singh Surjit

机构信息

Pediatrics, All India Institute of Medical Sciences, Rishikesh, IND.

Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, USA.

出版信息

Cureus. 2020 Apr 29;12(4):e7890. doi: 10.7759/cureus.7890.

DOI:10.7759/cureus.7890
PMID:32489744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7255548/
Abstract

Pulmonary hemorrhage is an uncommon manifestation in children and is often associated with systemic lupus erythematosus. We report a case of an adolescent girl who presented to our hospital with recurrent episodes of fever, cough, and breathlessness. Later on, she was diagnosed with pulmonary hemosiderosis as a manifestation of systemic lupus erythematosus. She was started on immunosuppressive therapy initially with prednisolone and subsequently with azathioprine and hydroxychloroquine, which improved the clinical status of the child.

摘要

肺出血在儿童中是一种不常见的表现,且常与系统性红斑狼疮相关。我们报告一例青少年女性病例,她因反复发热、咳嗽和呼吸急促前来我院就诊。后来,她被诊断为系统性红斑狼疮表现的肺含铁血黄素沉着症。最初给予泼尼松龙进行免疫抑制治疗,随后加用硫唑嘌呤和羟氯喹,患儿的临床状况得到改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364e/7255548/5f46408358e3/cureus-0012-00000007890-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364e/7255548/6d973c6a70a4/cureus-0012-00000007890-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364e/7255548/5f46408358e3/cureus-0012-00000007890-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364e/7255548/6d973c6a70a4/cureus-0012-00000007890-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364e/7255548/5f46408358e3/cureus-0012-00000007890-i02.jpg

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本文引用的文献

1
Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: Histopathologic Features and Clinical Correlations.系统性红斑狼疮中的弥漫性肺泡出血:组织病理学特征与临床相关性
Case Rep Pathol. 2017;2017:1936282. doi: 10.1155/2017/1936282. Epub 2017 Apr 27.
2
Diffuse Alveolar Hemorrhage as a Manifestation of Childhood-Onset Systemic Lupus Erythematosus.弥漫性肺泡出血作为儿童期起病的系统性红斑狼疮的一种表现
Hosp Pediatr. 2016 Aug;6(8):496-500. doi: 10.1542/hpeds.2015-0281. Epub 2016 Jul 7.
3
Systemic lupus erythematosus complicated by diffuse alveolar haemorrhage: risk factors, therapy and survival.
系统性红斑狼疮并发弥漫性肺泡出血:危险因素、治疗和生存。
Lupus Sci Med. 2015 Sep 23;2(1):e000117. doi: 10.1136/lupus-2015-000117. eCollection 2015.
4
Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort.伴有和不伴有抗双链DNA抗体的系统性红斑狼疮:来自大型单中心队列的分析
Mediators Inflamm. 2015;2015:328078. doi: 10.1155/2015/328078. Epub 2015 May 6.
5
Idiopathic pulmonary haemosiderosis presenting as severe iron deficiency anaemia--a case from Pakistan.表现为严重缺铁性贫血的特发性肺含铁血黄素沉着症——来自巴基斯坦的一例病例
J Pak Med Assoc. 2012 Aug;62(8):845-7.
6
Alveolar hemorrhage: distinct features of juvenile and adult onset systemic lupus erythematosus.肺泡出血:青少年和成人发病系统性红斑狼疮的特征性表现。
Lupus. 2012 Jul;21(8):872-7. doi: 10.1177/0961203312441047. Epub 2012 Mar 16.
7
Predictors of mortality in diffuse alveolar haemorrhage associated with systemic lupus erythematosus.弥漫性肺泡出血相关性系统性红斑狼疮的死亡预测因素。
Lupus. 2011 May;20(6):568-74. doi: 10.1177/0961203310392430.
8
Idiopathic pulmonary hemosiderosis: a rare cause of iron-deficiency anemia in childhood.特发性肺含铁血黄素沉着症:儿童缺铁性贫血的罕见病因。
J Pediatr Hematol Oncol. 2011 May;33(4):e160-2. doi: 10.1097/MPH.0b013e318212a6df.
9
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia.特发性肺含铁血黄素沉着症:肺泡是对贫血的一种反应。
J Postgrad Med. 2011 Jan-Mar;57(1):57-60. doi: 10.4103/0022-3859.74290.
10
Maintenance therapy with dose-adjusted 6-mercaptopurine in idiopathic pulmonary hemosiderosis.采用剂量调整的6-巯基嘌呤对特发性肺含铁血黄素沉着症进行维持治疗。
Pediatr Pulmonol. 2008 Nov;43(11):1067-1071. doi: 10.1002/ppul.20894.