Ta Robert, Celli Romulo, West A Brian
Department of Pathology, Yale University, 310 Cedar Street, New Haven, CT 06510, USA.
Case Rep Pathol. 2017;2017:1936282. doi: 10.1155/2017/1936282. Epub 2017 Apr 27.
The case of a 16-year-old African-American girl with systemic lupus erythematosus, who developed diffuse alveolar hemorrhage with fatal consequences, is described. Diffuse alveolar hemorrhage is a rare but serious complication of systemic lupus. It occurs in three distinct but overlapping phenotypes, acute capillaritis, bland pulmonary hemorrhage, and diffuse alveolar damage, each of which is associated with a different group of underlying conditions. Diffuse alveolar hemorrhage is a medical emergency: choice of treatment depends on early diagnosis and determination of the underlying etiology. Acute infection, superimposed on diffuse alveolar hemorrhage in the setting of immune compromise, is often a terminal event, as in this case.
本文描述了一名16岁患有系统性红斑狼疮的非裔美国女孩的病例，她发生了弥漫性肺泡出血并导致死亡。弥漫性肺泡出血是系统性红斑狼疮一种罕见但严重的并发症。它以三种不同但相互重叠的表型出现，即急性毛细血管炎、单纯性肺出血和弥漫性肺泡损伤，每种表型都与不同的基础疾病相关。弥漫性肺泡出血是一种医疗急症：治疗方案的选择取决于早期诊断和潜在病因的确定。正如本病例所示，在免疫功能低下的情况下，急性感染叠加在弥漫性肺泡出血上往往是致命的。
