Department of Pharmacy, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430021, China.
Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430021, China.
Biomark Med. 2020 Jul;14(10):827-837. doi: 10.2217/bmm-2020-0254. Epub 2020 Jun 3.
We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. An increase in the severity of COVID-19 pneumonia was positively associated with lower levels of platelets and albumin (all p < 0.05). In the critical group, the plasma levels of albumin continued to have a significant association for the risk of nonsurvivors (p < 0.05), even after adjusting for confounding factors. Albumin levels could be used as an independent predictor of the risk of nonsurvivors in critically ill patients with COVID-19.
我们旨在探索与疾病进展或非幸存者风险相关的生物标志物。这项研究纳入了 134 名确诊 COVID-19 感染的住院患者。比较了中症、重症和危重症患者以及幸存者与非幸存者的结局。COVID-19 肺炎严重程度的增加与血小板和白蛋白水平降低呈正相关（均 p<0.05）。在危重症组中，白蛋白的血浆水平与非幸存者的风险仍存在显著关联（p<0.05），即使在调整了混杂因素后也是如此。白蛋白水平可作为 COVID-19 危重症患者非幸存者风险的独立预测因子。
