Laboratorio de Inmunotoxicología, Universidad Autónoma de Nayarit, Tepic Nayarit, México.
Centro Nayarita de Innovación y Transferencia de Tecnología A.C., Unidad Especializada Laboratorio Nacional de Investigación Para la Inocuidad Alimentaria (Laniia)-unidad Nayarit, Tepic, México.
Int J Environ Health Res. 2022 Feb;32(2):455-462. doi: 10.1080/09603123.2020.1773413. Epub 2020 Jun 3.
Spinosad and temefos are widely used pesticides for chemical control of dengue vector-borne disease (). The aim of this study was to compare the effect of acute exposure (7 days) to spinosad (0.5 mg A.I. L) and temefos (10 mg A.I. L), concentrations used by the Mexican Ministry of Health, on phagocytic capacity (PC) of mononuclear cells of guppies fish (), as well as to assess PC in fish, at 96 days after exposure to those pesticides. Obtained results indicated that spinosad did not alter PC, while an acute exposure to temefos significantly affected phagocytosis and this parameter was maintained downed even 96 days after the acute exposure, suggesting that the immunotoxic effects of temefos may be chronic.
多杀菌素和特美氟磷是广泛用于控制登革热媒介传播疾病的化学农药（）。本研究的目的是比较急性暴露（7 天）多杀菌素（0.5 毫克 AI/L）和特美氟磷（10 毫克 AI/L）对鳉鱼单核细胞吞噬能力（PC）的影响，这两种浓度均为墨西哥卫生部所采用，同时评估鱼类在接触这些农药 96 天后的 PC 值。研究结果表明，多杀菌素不会改变 PC 值，而急性暴露于特美氟磷会显著影响吞噬作用，即使在急性暴露 96 天后，该参数仍保持下降，表明特美氟磷的免疫毒性作用可能是慢性的。
