Laboratorio Nacional de Investigación para la Inocuidad Alimentaria (LANIIA)-Unidad Nayarit, Universidad Autónoma de Nayarit, Tepic 63173, Mexico.
Centro Universitario de los Altos, Departamento de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 47610, Mexico.
Int J Mol Sci. 2022 Apr 20;23(9):4523. doi: 10.3390/ijms23094523.
Organophosphorus pesticides (OPs) are widespread insecticides used for pest control in agricultural activities and the control of the vectors of human and animal diseases. However, OPs' neurotoxic mechanism involves cholinergic components, which, beyond being involved in the transmission of neuronal signals, also influence the activity of cytokines and other pro-inflammatory molecules; thus, acute and chronic exposure to OPs may be related to the development of chronic degenerative pathologies and other inflammatory diseases. The present article reviews and discusses the experimental evidence linking inflammatory process with OP-induced cholinergic dysregulation, emphasizing the molecular mechanisms related to the role of cytokines and cellular alterations in humans and other animal models, and possible therapeutic targets to inhibit inflammation.
有机磷农药（OPs）是广泛用于农业活动中防治害虫以及控制人类和动物疾病传播媒介的杀虫剂。然而，OPs 的神经毒性机制涉及胆碱能成分，这些成分除了参与神经元信号的传递外，还影响细胞因子和其他促炎分子的活性；因此，急性和慢性接触 OPs 可能与慢性退行性病变和其他炎症性疾病的发展有关。本文综述和讨论了将炎症过程与 OP 诱导的胆碱能失调联系起来的实验证据，强调了与细胞因子作用相关的分子机制以及人类和其他动物模型中细胞改变，并探讨了可能的抑制炎症的治疗靶点。
