左旋咪唑对小鼠体内麻风分枝杆菌的作用。
Effect of levamisole on Mycobacterium leprae in mice.
作者信息
Shepard C C, Van Landingham R, Walker L L
出版信息
Infect Immun. 1977 May;16(2):564-7. doi: 10.1128/iai.16.2.564-567.1977.
Abstract
Levamisole, an antihelminthic drug that is capable of enhancing immune responses in mice and in humans, was tested in experimental Mycobacterium leprae infections in mice by a number of schedules. Intermittent schedules were used, and administration of the drug was started (i) around the time of inoculation with M. leprae, (ii) when the M. leprae population was approaching the plateau level, (iii) after the onset of the plateau phase, or (iv) after BCG vaccination 28 days following the inoculation with M. leprae. No effect of drug could be discerned with any of the schedules.
摘要
左旋咪唑是一种能够增强小鼠和人类免疫反应的抗蠕虫药物，通过多种给药方案在小鼠实验性麻风分枝杆菌感染中进行了测试。采用了间歇性给药方案，药物给药开始于：(i) 接种麻风分枝杆菌前后；(ii) 麻风分枝杆菌数量接近平台期时；(iii) 平台期开始后；或 (iv) 在接种麻风分枝杆菌后28天进行卡介苗接种之后。在任何给药方案下均未发现该药物有效果。
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