麻风分枝杆菌免疫原性的热稳定性。
Heat stability of Mycobacterium leprae immunogenicity.
作者信息
Shepard C C, Walker L L, van Landingham R
出版信息
Infect Immun. 1978 Oct;22(1):87-93. doi: 10.1128/iai.22.1.87-93.1978.
Abstract
The protection provided to mice by vaccines administered intradermally was measured after footpad challenge with Mycobacterium leprae. The protection offered by M. leprae suspensions was not decreased when the vaccines were killed by 60 degrees C heat or at the higher temperatures tested, which included 215 degrees C (autoclave). Even highly purified suspensions retained their immunogenicity. In contrast, the vaccine protection provided by intradermal M. bovis (strain BCG) was markedly reduced when heated to 60 degrees C. The enlargement of the lymph nodes regional to the intradermal vaccines was measured and found generally to parallel the vaccine protection provided by M. leprae and by BCG.
摘要
在用麻风分枝杆菌对足垫进行攻击后，测量了皮内接种疫苗给予小鼠的保护作用。当疫苗在60℃加热或在包括215℃（高压灭菌）在内的更高测试温度下灭活时，麻风分枝杆菌悬液提供的保护作用并未降低。即使是高度纯化的悬液也保留了其免疫原性。相比之下，皮内接种牛分枝杆菌（卡介苗菌株）的疫苗在加热到60℃时，其保护作用明显降低。测量了皮内疫苗区域淋巴结的肿大情况，发现其总体上与麻风分枝杆菌和卡介苗提供的疫苗保护作用平行。
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