给小鼠接种疫苗以预防麻风分枝杆菌感染。
Vaccination of mice against Mycobacterium leprae infection.
作者信息
Singh N B, Lowe A C, Rees R J, Colston M J
机构信息
Laboratory for Leprosy and Mycobacterial Research, National Institute for Medical Research, London, United Kingdom.
出版信息
Infect Immun. 1989 Feb;57(2):653-5. doi: 10.1128/iai.57.2.653-655.1989.
Abstract
Intradermal immunization with killed Mycobacterium leprae renders mice immune to infection with viable M. leprae. This protection is long lasting and systemic in that immunization in the left flank results in protection in both the left and right footpads. Immunization with Mycobacterium vaccae was ineffective in protecting mice against M. leprae infection, while Mycobacterium bovis BCG provided partial protection. Mycobacterium habana TMC 5135 (now known as Mycobacterium simiae) was found to be as effective as M. leprae in protecting mice against footpad infection.
摘要
用灭活的麻风分枝杆菌进行皮内免疫可使小鼠对活的麻风分枝杆菌感染产生免疫。这种保护作用持久且具有全身性，因为在左侧腹进行免疫会导致左右脚垫都得到保护。用母牛分枝杆菌免疫在保护小鼠免受麻风分枝杆菌感染方面无效，而卡介苗提供了部分保护。发现哈瓦那分枝杆菌TMC 5135（现称为猿分枝杆菌）在保护小鼠免受脚垫感染方面与麻风分枝杆菌一样有效。
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