突破：高尔基衍生小泡有助于线粒体分裂。
Break on Through: Golgi-Derived Vesicles Aid in Mitochondrial Fission.
机构信息
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
出版信息
Cell Metab. 2020 Jun 2;31(6):1047-1049. doi: 10.1016/j.cmet.2020.05.010.
Abstract
Mitochondrial fission is sustained through contact with several organelles, including the endoplasmic reticulum, lysosomes, and the actin cytoskeleton. Nagashima et al. (2020) now demonstrate that PI(4)P-containing Golgi-derived vesicles also modulate mitochondrial fission, driven by Arf1 and PI(4)KIIIβ activity, identifying a new organelle contact involved in maintaining mitochondrial homeostasis.
摘要
线粒体的分裂通过与包括内质网、溶酶体和肌动蛋白细胞骨架在内的几种细胞器接触得以维持。Nagashima 等人（2020 年）现在证明，含有 PI(4)P 的高尔基体衍生小泡也通过 Arf1 和 PI(4)KIIIβ 的活性来调节线粒体的分裂，确定了一种新的参与维持线粒体动态平衡的细胞器接触。
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