Candel F J, Viñuela-Prieto J M, González Del Castillo J, Barreiro García P, Fragiel Saavedra M, Hernández Píriz A, Jiménez Virumbrales D, Canora Lebrato J, García de Casasola G, Gil Prieto R, San-Román Montero J, Ortega Anselmi J, Barba Martín R, Prados Roa F, Marco Martínez J, Zapatero Gaviria A
Francisco Javier Candel González. Clinical Microbiology and Infectious Diseases. Hospital Clínico San Carlos. Madrid. Spain. COVID-19 IFEMA Field Hospital.
Rev Esp Quimioter. 2020 Aug;33(4):258-266. doi: 10.37201/req/052.2020. Epub 2020 Jun 4.
The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We analyzed the usefulness of the SARS-CoV-2 rapid test of Autobio and tried to correlate its pattern with the severity of COVID19 infection.
We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls.
The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. All patients with SARS-CoV-2 PCR+ showed the corresponding IgG positivity, while these results were negative in all control individuals. A total of 26 (74%) cases also presented with positive IgM, 19 (83%) were severe-critical cases and 7 (58%) were mild-moderate cases. The IgM response lasted longer in the severe critical cases (mean: 29.7 days; SD: 8.4) compared to the moderate cases (mean: 21.2 days; SD: 2.0)..
Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection).
出于医学和公共卫生原因，对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染进行诊断至关重要，以便对病例进行最佳治疗并对疫情进行最佳控制。血清学检测可在病毒清除后检测无症状感染和新冠病例。我们分析了安图生物SARS-CoV-2快速检测的效用，并试图将其结果模式与新冠病毒感染的严重程度相关联。
我们分析了一种用于SARS-CoV-2的即时检验免疫球蛋白M（IgM）和/或免疫球蛋白G（IgG）检测在35例新冠患者[12例（34.3%）轻症-中症和23例（65.7%）重症-危重症]以及5名对照者中的准确性和临床效用，这些患者均入住马德里的一家野战医院。
从症状出现首日到抗体检测的平均时间为28天（标准差：8.7），根据疾病严重程度来看此时间相似。所有SARS-CoV-2聚合酶链反应（PCR）检测呈阳性的患者IgG均呈相应阳性，而所有对照个体的这些结果均为阴性。共有26例（74%）病例IgM也呈阳性，其中19例（83%）为重症-危重症病例，7例（58%）为轻症-中症病例。与中症病例（平均：21.2天；标准差：2.0）相比，重症-危重症病例中IgM反应持续时间更长（平均：29.7天；标准差：8.4）。
快速血清学检测对新冠患者的诊断有用（主要检测IgG），并且也可能与感染的严重程度相关（基于IgM检测）。
