Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
BMC Cardiovasc Disord. 2020 Jun 3;20(1):265. doi: 10.1186/s12872-020-01545-7.
To evaluate the association between apolipoprotein B gene polymorphism and coronary heart disease in some populations at home and abroad by means of meta-analysis.
Using the strict exclusion criteria for primary screening of the literature and applying the Hardy-Weinberg equilibrium to test the genetic balance of the selected literature. The corresponding models were selected according to the results of the heterogeneity test. The Begg's test and Egger's test were used to evaluate publication bias, and meta-analysis was performed using Stata 12.0.
The study included twelve articles. In the literature, a total of 1596 patients with coronary heart disease and 1431 controls.Meta-analysis results showed no statistical value in the following three genetic models: allelic comparison (a vs A,P = 0.811,OR = 0.95, 95%CI = 0.62-1.46), recessive genetic models (aa vs Aa/AA, P = 0.86,OR = 0.94, 95%CI = 0.45-1.96), or dominant genetic models (aa/Aa vs AA, P = 0.73,OR = 0.92, 95%CI = 0.58-1.47). Subgroup analysis based on ethnicity showed allelic comparison (a vs A,P = 0.464,OR = 1.32, 95%CI = 0.63-2.78), recessive genetic models (aa vs Aa/AA, P = 0.422,OR = 1.52, 95%CI = 0.55-4.21), and dominant genetic models (aa/Aa vs AA, P = 0.551,OR = 1.26, 95%CI = 0.58-2.73) in Asians, allelic comparison (a vs A,P = 0.410,OR = 0.79, 95%CI = 0.45-1.39), recessive genetic models (aa vs Aa/AA, P = 0.041,OR = 0.75,95%CI = 0.57-0.99),dominant genetic models (aa/Aa vs AA, P = 0.385,OR = 0.75, 95%CI = 0.40-1.43) in Caucasian; CONCLUSION: The ApoB(apolipoprotein B) XbaI locus is not a risk factor when it comes to the development of coronary heart disease in the domestic and international populations included in this paper. In Caucasians, people carrying the aa genotype may be less susceptible to CHD (coronary heart disease). The results of recessive genetic models have to take the effect of heterogeneity and sample sizes into account. Further research may require a larger and more rigorous research design.
通过荟萃分析，评价载脂蛋白 B 基因多态性与国内外部分人群冠心病的相关性。
通过文献的严格初筛标准，并采用 Hardy-Weinberg 平衡检验选择文献的遗传平衡。根据异质性检验结果选择相应模型。采用 Begg 检验和 Egger 检验评估发表偏倚，并采用 Stata12.0 进行荟萃分析。
该研究共纳入 12 篇文献。文献中，共纳入冠心病患者 1596 例，对照组 1431 例。荟萃分析结果显示，以下三种遗传模型均无统计学意义：等位基因比较（a 对 A，P=0.811，OR=0.95，95%CI=0.62-1.46）、隐性遗传模型（aa 对 Aa/AA，P=0.86，OR=0.94，95%CI=0.45-1.96）或显性遗传模型（aa/Aa 对 AA，P=0.73，OR=0.92，95%CI=0.58-1.47）。基于种族的亚组分析显示，等位基因比较（a 对 A，P=0.464，OR=1.32，95%CI=0.63-2.78）、隐性遗传模型（aa 对 Aa/AA，P=0.422，OR=1.52，95%CI=0.55-4.21）和显性遗传模型（aa/Aa 对 AA，P=0.551，OR=1.26，95%CI=0.58-2.73）在亚洲人中，等位基因比较（a 对 A，P=0.410，OR=0.79，95%CI=0.45-1.39）、隐性遗传模型（aa 对 Aa/AA，P=0.041，OR=0.75，95%CI=0.57-0.99）和显性遗传模型（aa/Aa 对 AA，P=0.385，OR=0.75，95%CI=0.40-1.43）在白种人中；结论：在纳入本文的国内外人群中，载脂蛋白 B(XbaI 位点）不是冠心病发展的危险因素。在白种人中，携带 aa 基因型的人可能对 CHD（冠心病）的易感性较低。隐性遗传模型的结果需要考虑异质性和样本量的影响。进一步的研究可能需要更大和更严格的研究设计。
