Fawwad Asher, Waris Nazish, Askari Saima, Ogle Graham, Ahmedani Muhammad Yakoob, Basit Abdul
Asher Fawwad, PhD. Professor & Head of the Biochemistry Department (BMU), Honorary Research Director (BIDE), Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan. Baqai Medical University (BMU), Karachi, Pakistan.
Nazish Waris, M.Phil. Clinical Biochemistry and Psychopharmacology Research Unit Department of Biochemistry, University of Karachi-Pakistan Research Associate, Research Department (BIDE-BMU), Baqai Institute of Diabetology and Endocrinology (BIDE), Karachi, Pakistan. Baqai Medical University (BMU), Karachi, Pakistan.
Pak J Med Sci. 2020 May-Jun;36(4):765-769. doi: 10.12669/pjms.36.4.1531.
To determine the relationship of C-peptide levels with duration of type 1 diabetes mellitus.
This prospective study was conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University (BMU), Karachi-Pakistan from December 2013 to December 2015. A total of 184 subjects were recruited during the study period, 100 in Group-A and 84 in Group-B. Subjects clinically diagnosed with type 1 diabetes Mellitus (T1DM) were categorized into two groups based on duration of diabetes: Group-A (with ≤1-year duration of diabetes) and Group-B (with >1-year duration of diabetes). Ninety-nine of the 100 enrolled subjects in Group-A were diagnosed as having T1DM, with one subject who presented at 11.9 years of age and diagnosed with T2DM excluded from this study. Blood samples were drawn for biochemical parameters. Data for baseline characteristics and clinical parameters (HbA1c and C-peptide) were obtained from hospital management system of BIDE.
Fifty-seven (57.6%) subjects in Group-A, and 39 (46.4%) in Group-B were males. Mean±SD duration of diabetes (years) was 0.64±0.6 (range 0-1) in Group-A, and 7.65±5.5 (range 1-23) in Group-B. Family history of T1DM and T2DM was 1(1%) and 27(27.3%) in Group-A, and 8(9.52%) and 21(25%) in Group-B, respectively. Twenty-one (21.2%) subjects presented in diabetic ketoacidosis (DKA) in Group-A and 18(21.4%), in Group-B. Mean±SD for HbA1c was non-significantly higher in Group-A 11.12±2.31 compared to Group-B 10.42±1.45. Mean±SD for C-peptide was 1.91±1.53 ng/mL (0.60±0.481 nmol/L) in Group-A, and 1.82±1.01 (0.57±0.32 nmol/L) in Group-B (p=0.984).
The study found that subjects with longer duration of T1DM had non-significantly decreased C-peptide levels compared to a group in which C-peptide was measured at or soon after diagnosis. Furthermore, C-peptide levels in many subjects with longer duration were higher than expected in classic T1DM.
确定C肽水平与1型糖尿病病程之间的关系。
这项前瞻性研究于2013年12月至2015年12月在巴基斯坦卡拉奇巴凯医科大学巴凯糖尿病与内分泌研究所（BIDE）进行。研究期间共招募了184名受试者，A组100名，B组84名。临床诊断为1型糖尿病（T1DM）的受试者根据糖尿病病程分为两组：A组（糖尿病病程≤1年）和B组（糖尿病病程>1年）。A组100名入组受试者中有99名被诊断为T1DM，1名11.9岁就诊并被诊断为T2DM的受试者被排除在本研究之外。采集血样检测生化参数。基线特征和临床参数（糖化血红蛋白和C肽）数据来自BIDE医院管理系统。
A组57名（57.6%）受试者为男性，B组39名（46.4%）为男性。A组糖尿病平均病程（年）为0.64±0.6（范围0 - 1），B组为7.65±5.5（范围1 - 23）。A组T1DM家族史和T2DM家族史分别为1例（1%）和27例（27.3%），B组分别为8例（9.52%）和21例（25%）。A组21名（21.2%）受试者出现糖尿病酮症酸中毒（DKA），B组18名（21.4%）出现DKA。A组糖化血红蛋白的均值±标准差为11.12±2.31，略高于B组的10.42±1.45，但差异无统计学意义。A组C肽的均值±标准差为1.91±1.53 ng/mL（0.6±0.481 nmol/L），B组为1.82±1.01（0.57±0.32 nmol/L）（p = 0.984）。
研究发现，与诊断时或诊断后不久测量C肽的一组受试者相比，T1DM病程较长的受试者C肽水平略有下降，但差异无统计学意义。此外，许多病程较长的受试者的C肽水平高于经典T1DM的预期水平。
