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Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice.测量儿童重症哮喘中的炎症：临床实践中的生物标志物
Breathe (Sheff). 2020 Mar;16(1):190301. doi: 10.1183/20734735.0301-2019.
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Asthma Endotyping and Biomarkers in Childhood Asthma.儿童哮喘的内型分类及生物标志物
Pediatr Allergy Immunol Pulmonol. 2018 Jun 1;31(2):44-55. doi: 10.1089/ped.2018.0886.
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Biomarkers of asthma.哮喘的生物标志物。
Minerva Med. 2022 Feb;113(1):63-78. doi: 10.23736/S0026-4806.21.07381-X. Epub 2021 Jul 8.
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Role of T2 inflammation biomarkers in severe asthma.T2炎症生物标志物在重度哮喘中的作用。
Curr Opin Pulm Med. 2016 Jan;22(1):59-68. doi: 10.1097/MCP.0000000000000231.
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Critical evaluation of asthma biomarkers in clinical practice.临床实践中哮喘生物标志物的批判性评估。
Front Med (Lausanne). 2022 Oct 10;9:969243. doi: 10.3389/fmed.2022.969243. eCollection 2022.
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Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation.理解 2 型炎症致不可控持续性哮喘治疗中的关键问题。
Eur Respir J. 2021 Aug 5;58(2). doi: 10.1183/13993003.03393-2020. Print 2021 Aug.
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Update on Inflammatory Biomarkers for Defining Asthma Phenotype.用于定义哮喘表型的炎症生物标志物的最新进展
Allergy Asthma Immunol Res. 2024 Sep;16(5):462-472. doi: 10.4168/aair.2024.16.5.462.
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Immunological biomarkers in severe asthma.严重哮喘的免疫生物标志物。
Semin Immunol. 2019 Dec;46:101332. doi: 10.1016/j.smim.2019.101332. Epub 2019 Nov 14.
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Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.通过有创和无创方法评估的重度哮喘气道炎症：嗜酸性粒细胞和非嗜酸性粒细胞表型
J Allergy Clin Immunol. 2006 Nov;118(5):1033-9. doi: 10.1016/j.jaci.2006.08.003. Epub 2006 Sep 25.
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Biomarkers in the Management of Difficult Asthma.难治性哮喘管理中的生物标志物
Curr Top Med Chem. 2016;16(14):1561-73. doi: 10.2174/1568026616666151015093406.
引用本文的文献
1
Dupilumab Plus Medium-Dose Inhaled Corticosteroid (ICS) Improves Outcomes Compared With Placebo Plus Continued High-Dose ICS in Children With Uncontrolled Moderate-to-Severe Type 2 Asthma.与安慰剂加持续高剂量吸入性糖皮质激素（ICS）相比，度普利尤单抗加中等剂量ICS可改善未得到控制的中度至重度2型哮喘儿童的治疗效果。
Pediatr Pulmonol. 2025 Jul;60(7):e71197. doi: 10.1002/ppul.71197.
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Neutrophil-to-lymphocyte ratio, platelets-to-lymphocyte ratio, and red cell distribution width as prognostic indicators for length of hospital stay in pediatric asthma.中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及红细胞分布宽度作为小儿哮喘住院时间的预后指标。
Saudi Med J. 2025 Feb;46(2):143-149. doi: 10.15537/smj.2025.46.2.20240934.
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Association of relative fat mass with asthma: inflammatory markers as potential mediators.相对脂肪量与哮喘的关联：炎症标志物作为潜在介质
Lipids Health Dis. 2025 Jan 14;24(1):13. doi: 10.1186/s12944-024-02428-y.
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Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab.用于监测接受美泊利珠单抗或奥马珠单抗治疗的重度哮喘的多组学整合分析。
Allergy. 2025 Jul;80(7):1899-1911. doi: 10.1111/all.16434. Epub 2024 Dec 18.
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Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain.西班牙儿童重度嗜酸性粒细胞性哮喘的预后因素：一项前瞻性队列研究
J Clin Med. 2024 Nov 27;13(23):7202. doi: 10.3390/jcm13237202.
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Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma.通过对比机器学习进行表观遗传学患者分层可优化哮喘少数族裔儿童的标志性生物标志物。
Res Sq. 2024 Sep 13:rs.3.rs-5066762. doi: 10.21203/rs.3.rs-5066762/v1.
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The Influence of Neurotrophins on the Brain-Lung Axis: Conception, Pregnancy, and Neonatal Period.神经营养因子对脑-肺轴的影响：受孕、妊娠及新生儿期
Curr Issues Mol Biol. 2024 Mar 15;46(3):2528-2543. doi: 10.3390/cimb46030160.
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Endotypes of Paediatric Cough-Do They Exist and Finding New Techniques to Improve Clinical Outcomes.小儿咳嗽的内型——它们是否存在以及寻找改善临床结果的新技术
J Clin Med. 2024 Jan 28;13(3):756. doi: 10.3390/jcm13030756.
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4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development.辛基衣康酸酯通过抑制趋化因子和嗜酸性粒细胞的发育缓解气道嗜酸性粒细胞炎症。
J Immunol. 2024 Jan 1;212(1):13-23. doi: 10.4049/jimmunol.2300155.
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Sputum induction and its diagnostic applications in inflammatory airway disorders: a review.痰液诱导及其在炎症性气道疾病中的诊断应用：综述
Front Allergy. 2023 Oct 12;4:1282782. doi: 10.3389/falgy.2023.1282782. eCollection 2023.
本文引用的文献
1
Living well with severe asthma.重度哮喘患者的良好生活状态。
Breathe (Sheff). 2019 Jun;15(2):e40-e49. doi: 10.1183/20734735.0165-2019.
2
Anxiety and Depression in Adolescents with Severe Asthma and in Their Parents: Preliminary Results after 1 Year of Treatment.重度哮喘青少年及其父母的焦虑和抑郁：治疗1年后的初步结果
Behav Sci (Basel). 2019 Jul 13;9(7):78. doi: 10.3390/bs9070078.
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Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives.儿童和青少年重度哮喘的靶向治疗：现状和未来展望。
Paediatr Drugs. 2019 Aug;21(4):215-237. doi: 10.1007/s40272-019-00345-7.
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Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective.儿童哮喘中的呼出气冷凝物：综述与当前观点
Front Pediatr. 2019 Apr 25;7:150. doi: 10.3389/fped.2019.00150. eCollection 2019.
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Exploring the Utility of Noninvasive Type 2 Inflammatory Markers for Prediction of Severe Asthma Exacerbations in Children and Adolescents.探讨非侵入性 2 型炎症标志物在预测儿童和青少年重度哮喘发作中的效用。
J Allergy Clin Immunol Pract. 2019 Nov-Dec;7(8):2624-2633.e2. doi: 10.1016/j.jaip.2019.04.043. Epub 2019 May 14.
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Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children.骨膜蛋白（Periostin），2 型生物标志物，与哮喘过敏儿童的哮喘控制等级无关。
Respir Med. 2019 May;151:118-120. doi: 10.1016/j.rmed.2019.04.010. Epub 2019 Apr 11.
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Periostin: An emerging biomarker for allergic diseases.骨膜蛋白：一种新兴的过敏性疾病生物标志物。
Allergy. 2019 Nov;74(11):2116-2128. doi: 10.1111/all.13814. Epub 2019 May 3.
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Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma.儿童重症、难治性哮喘的肺灌洗粒细胞模式与临床表型。
J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):1803-1812.e10. doi: 10.1016/j.jaip.2018.12.027. Epub 2019 Jan 14.
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Severe asthma in children: Evaluation and management.儿童严重哮喘：评估与管理。
Allergol Int. 2019 Apr;68(2):150-157. doi: 10.1016/j.alit.2018.11.007. Epub 2019 Jan 14.
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Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis.电子鼻在哮喘和囊性纤维化儿童中的可行性和诊断准确性。
J Breath Res. 2019 May 8;13(3):036009. doi: 10.1088/1752-7163/aae158.
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