O'Farrell Hannah E, Kok Hing Cheong, Goel Suhani, Chang Anne B, Yerkovich Stephanie T
NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia.
Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia.
J Clin Med. 2024 Jan 28;13(3):756. doi: 10.3390/jcm13030756.
Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children.
慢性咳嗽是许多儿童肺部疾病的常见症状。鉴于慢性咳嗽的表型异质性，需要通过内型分型进行更好的特征描述，以提供诊断确定性、精准治疗并确定病理生物学机制。本综述总结了气道疾病，特别是与儿童相关的气道疾病中近期的内型分型发现，并描述了定义内型所需的多组学方法。还讨论了可能有助于内型分型和生物标志物发现的潜在生物样本。确定慢性咳嗽的内型分型可能会为儿童提供个性化医疗并改善临床结局。
