School of Medicine, Cardiff University, Cardiff, UK.
School of Healthcare Sciences, Cardiff University, Cardiff, UK.
Acta Psychiatr Scand. 2020 Aug;142(2):141-151. doi: 10.1111/acps.13200. Epub 2020 Jun 28.
To explore the potential efficacy of multi-modular motion-assisted memory desensitization and reprocessing (3MDR) in British military veterans with treatment-resistant service-related PTSD.
Exploratory single-blind, randomized, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.
A total of 42 participants (all male) were randomized with 83% retention at 12 weeks and 86% at 26 weeks. The difference in mean Clinician-Administered PTSD Scale for DSM-5 scores between the immediate and delayed 3MDR arms was -9.38 (95% CI -17.33 to -1.44, P = 0.021) at 12 weeks and -3.59 (-14.39 to 7.20, P = 0.513) at 26 weeks when both groups had received 3MDR. The likely effect size of 3MDR was found to be 0.65. Improvements were maintained at 26-week follow-up. 3MDR was found to be acceptable to most, but not all, participants. Several factors that may impact efficacy and acceptability of 3MDR were identified.
3MDR is a promising new intervention for treatment-resistant PTSD with emerging evidence of effect.
探索多模块运动辅助记忆脱敏再处理（3MDR）在有治疗抵抗性服务相关 PTSD 的英国退伍军人中的潜在疗效。
探索性单盲、随机、平行臂、交叉对照试验，嵌套过程评估以评估保真度、依从性和影响结果的因素。
共有 42 名参与者（均为男性）被随机分配，12 周时有 83%的保留率，26 周时有 86%的保留率。在即时和延迟的 3MDR 臂之间，DSM-5 临床医生管理 PTSD 量表的平均分数差异为 -9.38（95%CI -17.33 至 -1.44，P = 0.021），在 12 周时有 3MDR，差异为 -3.59（-14.39 至 7.20，P = 0.513），当两组都接受了 3MDR。3MDR 的可能效应大小被发现为 0.65。在 26 周随访时，改善得以维持。3MDR 被大多数参与者接受，但不是所有参与者。确定了一些可能影响 3MDR 的疗效和可接受性的因素。
3MDR 是一种有治疗抵抗性 PTSD 的有前途的新干预措施，具有疗效的初步证据。
