Deng Yu-Jiao, Zhagn Ding-Kun, Liu Qian, Pei Jin, Guo Zhi-Ping, Han Li, Ma Hong-Yan, Xu Run-Chun
State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
Sichuan Houde Pharmaceutical Technology Co., Ltd. Chengdu 610041, China.
Zhongguo Zhong Yao Za Zhi. 2020 May;45(10):2353-2359. doi: 10.19540/j.cnki.cjcmm.20200221.303.
Animal medicines have been called "medicine with affinity to flesh and blood" by doctors of all ages, which always act as an important branch of Chinese medicine. They have various types, extensive sources and long application history, with unique cli-nical effects in anti-coagulation, anti-thrombosis, anti-fatigue, immune regulation, anti-tumor, anti-convulsion and so on. Most animal medicines contain proteins, fatty acids, and trimethylamine oxides, which are prone to decomposition and produce substances such as biological amines, aldehydes, ketones, alcohols, trimethylamine and ammonia with unpleasant odors. The stench produced by the combination of various odors can easily cause side effects such as nausea and vomiting, which would probably affect the drug compliance and clinical efficacy in patients, and block the development of high-quality animal medicines. At present, we have insufficient understanding on sources and formation mechanism of the stench of animal medicines, lacking development of taste-masking technology. Therefore, the universality, formation, vomiting mechanism, evaluation methods, and masking technology of stench of animal medicines were summarized in this paper, so as to deepen the recognition of stench, provide references for the development of animal medicines deodorization technology, enhance patients' compliance with animal medicines, and promote animal drugs to better serve public health in the new era.
