Ma Le-le, Lin Jun-Zhi, Liu Hai-Yan, Liu Hui-Min, Huang Wei, Tan Peng, Han Li, Xu Run-Chun, Zhang Ding-Kun
State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, College of Pharmacy,Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
Central Laboratory, Teaching Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072, China.
Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3608-3616. doi: 10.19540/j.cnki.cjcmm.20200113.403.
Fatigue is a widespread and complex physiological phenomenon. Chronic fatigue can lead to cardiovascular dysfunction, mental disorders and other serious pathological reactions. Therefore, how to relieve fatigue accurately and effectively is an important proposition to implement the concept of "Healthy China" in the new era. As an important part of Chinese medicine health industry, Chinese medicine health food has been developing rapidly in recent years. At present, there are 1 157 kinds of anti-fatigue health food on the market in China, most of which are single Chinese medicine and its compound. However, their functions are generally labeled as "anti-fatigue", and their function positioning is too extensive and unclear. With the deepened understanding of fatigue classification and its physiological and pathological basis, it is urgent to be combined with the progress of modern chemical and pharmacological stu-dies to differentiate and precisely position the anti-fatigue health effects of traditional Chinese medicine. For this purpose, the classifications of fatigue were summarized in this paper, and the mechanism of fatigue was explained from the aspects of energy metabolism, accumulation of metabolites, oxidative stress, inflammation, hypothalamus pituitary adrenal axis and so on. We selected 10 traditional Chinese medicines which are most frequently used in health food, analyzed their anti-fatigue effect mechanisms, and summarized the best types of anti-fatigue food, so as to promote the scientific development of anti-fatigue health food industry, expand the market application scope of anti-fatigue health food, better respond to the construction of a healthy China and serve for people's health.
疲劳是一种广泛存在且复杂的生理现象。慢性疲劳可导致心血管功能障碍、精神障碍等严重病理反应。因此，如何准确有效地缓解疲劳是新时代贯彻“健康中国”理念的重要命题。中药保健食品作为中医药健康产业的重要组成部分，近年来发展迅速。目前，我国市场上有1157种抗疲劳保健食品，其中大部分为单味中药及其复方制剂。然而，它们的功能普遍标注为“抗疲劳”，功能定位过于宽泛且不明确。随着对疲劳分类及其生理病理基础认识的深入，迫切需要结合现代化学和药理学研究进展，对中药抗疲劳保健作用进行差异化和精准定位。为此，本文总结了疲劳的分类，并从能量代谢、代谢产物蓄积、氧化应激、炎症、下丘脑-垂体-肾上腺轴等方面阐释了疲劳的机制。我们选取了保健食品中最常用的10味中药，分析其抗疲劳作用机制，总结出最佳抗疲劳食品类型，以推动抗疲劳保健食品产业科学发展，扩大抗疲劳保健食品市场应用范围，更好地响应健康中国建设，服务人民健康。
