Department of Pharmacognosy, College of Pharmacy, Najran University, Najran 55461, Saudi Arabia.
Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-branch, Assiut 71524, Egypt.
Nat Prod Res. 2022 Jan;36(1):177-185. doi: 10.1080/14786419.2020.1774757. Epub 2020 Jun 4.
Three new [nilotinins M8‒M10 (‒)] and two known [tamarixinin A () and gemin D ()] ellagitannins and seven simple phenolics [gallic acid (), methyl gallate (), 3,4-di--methylgallic acid (), ellagic acid (), 3--methylellagic acid (), methyl ferulate 3--sulphate (), and 7,4'-di--methylkaempferol ()] were isolated from the halophytic plant (Ehrenb.) Bunge (Tamaricaceae). Their structures were determined based on intensive spectroscopic studies and comparisons with reported data. Compounds , and - were evaluated for their cytotoxicity against lung adenocarcinoma cell line (A549) and anti-leishmanial activity against . Compounds , and showed promising cytotoxic properties against A549 (IC 29 ± 2.3, 10.5 ± 0.7, and 20.7 ± 1.9 μg/mL), while compounds and showed higher growth-inhibitory effects against promastigotes (IC 40.5 ± 2.7 and 38.4 ± 2.5 μg/mL), as compared with the standards doxorubicin (IC 0.42 µg/mL) and miltefosine (IC 9.43 μg/mL), respectively.
从盐生植物 （Ehrenb.）Bunge（柽柳科）中分离得到三个新的[尼洛替尼 M8-M10（-）]和两个已知的[柽柳素 A（）和双 D（）]鞣花单宁以及七个简单酚类[没食子酸（）、甲基没食子酸（）、3,4-二--甲基没食子酸（）、鞣花酸（）、3--甲基鞣花酸（）、甲基阿魏酸 3--硫酸盐（）和 7,4'-二--甲基山柰酚（）]。基于深入的光谱研究和与报道数据的比较，确定了它们的结构。化合物 、 和 - 对肺腺癌细胞系（A549）的细胞毒性和对 的抗利什曼原虫活性进行了评估。化合物 、 和 对 A549 表现出有前途的细胞毒性（IC 29 ± 2.3、10.5 ± 0.7 和 20.7 ± 1.9 μg/mL），而化合物 、 和 对 前鞭毛体的生长抑制作用更强（IC 40.5 ± 2.7 和 38.4 ± 2.5 μg/mL），与标准药物多柔比星（IC 0.42 μg/mL）和米替福新（IC 9.43 μg/mL）相比。
