Orabi Mohamed A A, Salem-Bekhit Mounir M, Taha Ehab I, Abdel-Sattar El-Shaymaa, Alqahtani Omaish Salman, Al-Joufi Fakhria A, Abdel-Wahab Basel A, Alshabi Ali Mohamed, Alyami Hamad S, Ahmad Javed, Hatano Tsutomu
Department of Pharmacognosy, College of Pharmacy, Najran University, Najran 1988, Najran, Saudi Arabia.
Kyyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Riyadh, Saudi Arabia.
Pharmaceuticals (Basel). 2022 Feb 11;15(2):216. doi: 10.3390/ph15020216.
The application of plant extracts or plant-derived compounds in the green synthesis of metal nanoparticles (NPs) was researched. Determining the exact metabolite implicated in the formation of NPs would necessitate comprehensive investigations. Copper nanoparticles (CuNPs) are gaining a lot of attention because of their unique properties and effectiveness against a wide range of bacteria and fungi, as well as their potential for usage in catalytic, optical, electrical, and microelectronics applications. In the course of this study, we aimed to formulate CuNPs utilizing pure tamarixinin A (TA) ellagitannin isolated from galls. The main particle size of the formed CuNPs was 44 ± 1.7 nm with zeta potential equal to -23.7 mV, which emphasize the stability of the CuNPs. The X-ray diffraction spectroscopy showed a typical centered cubic crystalline structure phase of copper. Scanning electron microscopy images were found to be relatively spherical and homogeneous in shape. The antimicrobial properties of TA, as well as its mediated CuNPs, have been evaluated through well diffusion assays against four bacterial, NCTC 10400, ATCC 25923, ATCC 25922, and ATCC 27853, and two fungal, and , strains. The distinctive antimicrobial activities were noted against the fungal strains and the Gram-negative bacterial strains ATCC 27853, and ATCC 25922. In conclusion, CuNPs mediated by TA can be applied for combating a wide range of bacterial and fungal species especially , , and in a variety of fields.
研究了植物提取物或植物衍生化合物在金属纳米颗粒（NPs）绿色合成中的应用。确定参与纳米颗粒形成的确切代谢物需要进行全面的研究。铜纳米颗粒（CuNPs）因其独特的性质、对多种细菌和真菌的有效性以及在催化、光学、电学和微电子应用中的潜在用途而备受关注。在本研究过程中，我们旨在利用从没食子中分离出的纯塔拉辛宁A（TA）鞣花单宁来制备CuNPs。所形成的CuNPs的主要粒径为44±1.7nm，zeta电位为-23.7mV，这强调了CuNPs的稳定性。X射线衍射光谱显示出典型的铜的面心立方晶体结构相。扫描电子显微镜图像显示形状相对呈球形且均匀。通过针对四种细菌（NCTC 10400、ATCC 25923、ATCC 25922和ATCC 27853）以及两种真菌（和）菌株的平板扩散试验，评估了TA及其介导的CuNPs的抗菌性能。观察到对真菌菌株以及革兰氏阴性细菌菌株ATCC 27853和ATCC 25922具有独特的抗菌活性。总之，TA介导的CuNPs可用于对抗多种细菌和真菌物种，尤其是在各个领域中的、和。
