慢性淋巴细胞白血病中的自身免疫
Autoimmunity in chronic lymphocytic leukaemia.
作者信息
Lischner M, Prokocimer M, Zolberg A, Shaklai M
机构信息
Haematology Division, Beilinson Medical Center, Petah Tiqva.
出版信息
Postgrad Med J. 1988 Aug;64(754):590-2. doi: 10.1136/pgmj.64.754.590.
Seventy-nine patients with chronic lymphocytic leukaemia were evaluated for the presence of autoimmune diseases and autoantibodies. One patient has polymyositis and two additional patients presented with features suggestive of pernicious anaemia and chronic active hepatitis. The Coombs' direct test was positive in 7% and immune thrombocytopenia was present in 8.1% of patients. Five (7%) patients had M-protein in the serum. No increased frequency of other autoantibodies was noted in our study group. We conclude that the propensity to develop antibodies is restricted only to the haematopoietic system and that there is no increased frequency of non-haematological autoimmune diseases in chronic lymphatic leukaemia.
对79例慢性淋巴细胞白血病患者进行了自身免疫性疾病和自身抗体的评估。1例患者患有多发性肌炎，另有2例患者表现出恶性贫血和慢性活动性肝炎的特征。直接抗人球蛋白试验在7%的患者中呈阳性，8.1%的患者存在免疫性血小板减少症。5例（7%）患者血清中存在M蛋白。在我们的研究组中未发现其他自身抗体频率增加。我们得出结论，产生抗体的倾向仅局限于造血系统，慢性淋巴细胞白血病中非血液系统自身免疫性疾病的发生率没有增加。
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