Barrett S P, Gill O N, Mellor J A, Bryant J C
Department of Microbiology, Southend Hospital, Westcliffe-on-Sea, Essex.
Postgrad Med J. 1988 Aug;64(754):606-9. doi: 10.1136/pgmj.64.754.606.
Over a five year period beginning in 1981, during which control measures were applied intermittently, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) isolates increased steadily within a twin site general hospital. A retrospective chart review of 154 patients identified in 1984-1985 showed that the MRSA 'definitely' contributed to three deaths (2%) and 'probably' contributed to a further 15 (10%). The prolonged median duration of hospital admission (22 days) before first isolation of MRSA, together with the clustering of cases in time on certain wards, suggested that most, if not all, affected patients acquired the MRSA in hospital. As the virulence of MRSA in our outbreak appeared the same as that reported from teaching hospitals, MRSA control measures need to be comprehensively applied in general hospitals.
从1981年开始的五年期间，一家双院区综合医院间歇性地采取了控制措施，耐甲氧西林金黄色葡萄球菌（MRSA）分离株的发生率稳步上升。对1984年至1985年期间确诊的154例患者进行的回顾性病历审查显示，MRSA“肯定”导致了3例死亡（2%），“可能”导致了另外15例死亡（10%）。首次分离出MRSA之前患者住院时间的中位数较长（22天），以及某些病房病例在时间上的聚集情况表明，即使不是所有受影响的患者，大多数也是在医院感染了MRSA。由于本次疫情中MRSA的毒力似乎与教学医院报告的相同，因此需要在综合医院全面应用MRSA控制措施。
