Boyce J M, Landry M, Deetz T R, DuPont H L
Infect Control. 1981 Mar-Apr;2(2):110-6. doi: 10.1017/s0195941700053881.
In a six-month period in 1978 61 patients at a university hospital became colonized or infected with methicillin-resistant Staphylococcus aureus (MRSA). Ninety-three percent of patients with MRSA were on surgical services. Patients with burns acquired MRSA more frequently than did other acutely ill surgical patients (p less than .001), and often remained colonized for 30 days or more. The interval between admission and acquisition of S. aureus, number of antibiotics received, duration of antibiotic therapy before becoming colonized, and cost of hospitalization, were significantly greater in patients with MRSA infection than in matched controls with nosocomial methicillin-sensitive S. aureus infections. Acquisition of MRSA was epidemiologically associated with exposure to certain hospital personnel. Fourteen (6%) of 220 personnel exposed to MRSA patients harbored MRSA intranasally. Three of 14 colonized personnel carried MRSA intermittently for three or more months. Appropriate control measures failed to terminate the outbreak.
1978年的六个月期间，一所大学医院有61名患者被耐甲氧西林金黄色葡萄球菌（MRSA）定植或感染。93%的MRSA患者接受外科治疗。烧伤患者比其他急性病外科患者更频繁地感染MRSA（p小于0.001），并且常常被定植30天或更长时间。MRSA感染患者从入院到感染金黄色葡萄球菌的间隔时间、接受抗生素的数量、在被定植前抗生素治疗的持续时间以及住院费用，均显著高于患医院内甲氧西林敏感金黄色葡萄球菌感染的匹配对照患者。MRSA的获得在流行病学上与接触某些医院工作人员有关。接触MRSA患者的220名工作人员中有14名（6%）鼻腔内携带MRSA。14名被定植的工作人员中有3名间歇性携带MRSA达三个月或更长时间。适当的控制措施未能终止疫情爆发。
