Boyce J M, White R L, Causey W A, Lockwood W R
JAMA. 1983 May 27;249(20):2803-7.
During a 3 1/2-year period (January 1978 through June 1981), 245 patients in a university hospital became colonized or infected with methicillin-resistant Staphylococcus aureus. During the first 18 months, the incidence of colonization and infection was only 0.05%. After a focal outbreak of methicillin-resistant S aureus in the burn unit, acquisition of the organism by patients on other wards increased significantly. Nonburn patients acquired the organism more often during time periods when newly admitted burn patients acquired methicillin-resistant S aureus. After the burn unit was closed, acquisition of the organism among nonburn patients on adult surgical and medical services decreased significantly. A questionnaire survey of other institutions disclosed that large outbreaks of this infection occurred more frequently in hospitals with burn units. These studies suggest that the occurrence of methicillin-resistant S aureus infections in burn units may lead to increased transmission of the organism to nonburn patients and that control of the infection in such units may reduce spread of the organism to patients without burns.
在3年半的时间里（1978年1月至1981年6月），一所大学医院的245名患者被耐甲氧西林金黄色葡萄球菌定植或感染。在最初的18个月里，定植和感染的发生率仅为0.05%。烧伤病房发生耐甲氧西林金黄色葡萄球菌局部暴发后，其他病房患者感染该病菌的情况显著增加。非烧伤患者在新入院烧伤患者感染耐甲氧西林金黄色葡萄球菌的时间段内更易感染该病菌。烧伤病房关闭后，成人外科和内科服务科室的非烧伤患者感染该病菌的情况显著减少。对其他机构的问卷调查显示，这种感染的大规模暴发在设有烧伤病房的医院中更为频繁。这些研究表明，烧伤病房中耐甲氧西林金黄色葡萄球菌感染的发生可能导致该病菌向非烧伤患者的传播增加，而控制此类病房的感染可能会减少该病菌向未烧伤患者的传播。
