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非遗传风险因素在加剧酒精相关器官损伤中的作用。

Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage.

机构信息

Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, United States; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.

Department of Biochemistry & Molecular Biology, University of Nebraska Medical Center, Omaha, NE, United States.

出版信息

Alcohol. 2020 Sep;87:63-72. doi: 10.1016/j.alcohol.2020.05.002. Epub 2020 Jun 1.

Abstract

This review provides a summary of the symposium titled "Role of Non-Genetic Risk Factors in Exacerbating Alcohol-Related Organ Damage", which was held at the 42nd Annual Meeting of the Research Society on Alcoholism. The goals of the symposium were to provide newer insights into the role of non-genetic factors, including specific external factors, notably infectious agents or lifestyle factors, that synergistically act to exacerbate alcohol pathogenicity to generate more dramatic downstream biological defects. This summary of the symposium will benefit junior/senior basic scientists and clinicians currently investigating/treating alcohol-induced organ pathology, as well as undergraduate, graduate, and post-graduate students and fellows.

摘要

本综述提供了在第 42 届酒精研究学会年会上举行的题为“非遗传因素在加剧酒精相关器官损伤中的作用”研讨会的总结。研讨会的目标是提供对非遗传因素作用的新见解,包括特定的外部因素,特别是传染性病原体或生活方式因素,它们协同作用加剧酒精的致病性,产生更明显的下游生物学缺陷。本研讨会综述将使目前研究/治疗酒精引起的器官病理学的初级/高级基础科学家和临床医生、本科生、研究生和博士后受益。

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