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Asymmetric distribution of dynamin-2 and β-catenin relative to tight junction spikes in alveolar epithelial cells.肺泡上皮细胞中细胞质动力蛋白-2和β-连环蛋白相对于紧密连接刺的非对称分布。
Tissue Barriers. 2021 Jul 3;9(3):1929786. doi: 10.1080/21688370.2021.1929786. Epub 2021 Jun 10.
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Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation-induced systemic immunosuppression.角质形成细胞衍生的微囊泡颗粒介导紫外线 B 辐射诱导的全身免疫抑制。
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Cell Death in Liver Diseases: A Review.肝病中的细胞死亡:综述
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通过酒精对免疫、代谢和修复途径的影响来深入了解酒精介导的器官损伤机制:2021 年酒精与免疫学研究兴趣小组(AIRIG)会议综述。

New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

机构信息

Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Molecular Biology Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States; Medical Scientist Training Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, United States.

VA Rocky Mountain Mental Illness Research Education and Clinical Center, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO, United States; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Psychiatry and Neurology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Military and Veteran Microbiome: Consortium for Research and Education, Aurora, CO, United States.

出版信息

Alcohol. 2022 Sep;103:1-7. doi: 10.1016/j.alcohol.2022.05.004. Epub 2022 Jun 1.

DOI:10.1016/j.alcohol.2022.05.004
PMID:35659577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9994264/
Abstract

On November 19th, 2021, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at Loyola University Chicago Health Sciences Campus in Maywood, Illinois. The 2021 meeting focused on how alcohol misuse is linked to immune system derangements, leading to tissue and organ damage, and how this research can be translated into improving treatment of alcohol-related disease. This meeting was divided into three plenary sessions: the first session focused on how alcohol misuse affects different parts of the immune system, the second session presented research on mechanisms of organ damage from alcohol misuse, and the final session highlighted research on potential therapeutic targets for treating alcohol-mediated tissue damage. Diverse areas of alcohol research were covered during the meeting, from alcohol's effect on pulmonary systems and neuroinflammation to epigenetic changes, senescence markers, and microvesicle particles. These presentations yielded a thoughtful discussion on how the findings can lead to therapeutic treatments for people suffering from alcohol-related diseases.

摘要

2021 年 11 月 19 日,年度酒精与免疫学研究兴趣小组(AIRIG)会议在伊利诺伊州梅伍德的芝加哥洛约拉大学健康科学校区举行。2021 年的会议重点关注酒精滥用如何与免疫系统紊乱相关,导致组织和器官损伤,以及如何将这项研究转化为改善酒精相关疾病的治疗方法。本次会议分为三个全体会议:第一个会议重点介绍了酒精滥用如何影响免疫系统的不同部位,第二个会议介绍了酒精滥用导致器官损伤的机制研究,最后一个会议重点介绍了治疗酒精介导的组织损伤的潜在治疗靶点的研究。会议涵盖了酒精研究的多个领域,包括酒精对肺部系统和神经炎症的影响,以及表观遗传变化、衰老标志物和微泡颗粒。这些报告引发了关于这些发现如何为患有酒精相关疾病的人提供治疗的深思熟虑的讨论。