Department of Dermatology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China.
Department of Dermatology, Minda Hospital of Hubei Minzu University, Enshi 445000, China.
J Trace Elem Med Biol. 2020 Dec;62:126548. doi: 10.1016/j.jtemb.2020.126548. Epub 2020 May 20.
Several studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.
This systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.
A systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups.
Twenty-seven studies were identified with a total of 1315 patient and 7181 healthy controls. Compared with controls, no significant difference in selenium was found in patients with vitiligo (SMD = 0.53, 95% CI: -0.40 to 1.45), alopecia areata (SMD = 0.47, 95% CI: -2.72 and 3.65), or eczema (SMD = 0.12, 95% CI: -0.24 to 0.48). A lower selenium level was found in patients with psoriasis (SMD = -0.62, 95% CI: -1.15 to -0.10), acne vulgaris (SMD = -1.02, 95% CI: -1.45 to -0.60), chloric acne (SMD = -2.35, 95% CI: -3.15 to -1.55), and atopic dermatitis (SMD = -2.62, 95% CI: -3.00 to -2.24). As for disease severity, severe patients had a higher selenium level than mild patients in psoriasis (SMD = 0.72, 95% CI: 0.07-1.38), but no difference was found in vitiligo (SMD = -0.26, 95% CI: -2.38 to 1.85) and alopecia areata (SMD = 0.46, 95% CI: -0.34 to 1.26).
Selenium levels were associated with several skin diseases and the disease severity, and high selenium levels tended to be a protective factor in certain skin diseases.
多项研究调查了硒水平与皮肤病之间的关系，但结果不一致。
本系统评价和荟萃分析旨在评估硒水平与皮肤病之间的关系。
在公共数据库中进行系统搜索，以确定所有相关研究，并汇总研究特异性标准均数差值（SMD）和 95%置信区间（CI），以比较不同组之间的硒水平。
共确定了 27 项研究，共有 1315 名患者和 7181 名健康对照。与对照组相比，白癜风患者的硒水平无显著差异（SMD=0.53，95%CI：-0.40 至 1.45）、斑秃（SMD=0.47，95%CI：-2.72 至 3.65）或湿疹（SMD=0.12，95%CI：-0.24 至 0.48）。银屑病患者的硒水平较低（SMD=-0.62，95%CI：-1.15 至 -0.10）、寻常痤疮（SMD=-1.02，95%CI：-1.45 至 -0.60）、氯痤疮（SMD=-2.35，95%CI：-3.15 至 -1.55）和特应性皮炎（SMD=-2.62，95%CI：-3.00 至 -2.24）。就疾病严重程度而言，与轻度患者相比，重度患者的硒水平较高银屑病（SMD=0.72，95%CI：0.07-1.38），但在白癜风（SMD=-0.26，95%CI：-2.38 至 1.85）和斑秃（SMD=0.46，95%CI：-0.34 至 1.26）中未见差异。
硒水平与几种皮肤病和疾病严重程度有关，高硒水平往往是某些皮肤病的保护因素。
