Suhr O, Danielsson A, Nyhlin H, Truedsson H
Dept. of Medicine, University Hospital, Umeå, Sweden.
Scand J Gastroenterol. 1988 Dec;23(10):1187-94. doi: 10.3109/00365528809090189.
SeHCAT is a gamma-labelled synthetic bile acid, suitable for external measurements and detection of bile acid malabsorption. In this study 138 subjects were investigated with 75SeHCAT. The technique was modified by calculating the biologic half-life of the isotope (WBR-50) within 48 h. All patients with ileocaecal resection had reduced WBR-50 values, as did most (8 of 12) with Crohn's disease affecting the small bowel. Among patients with chronic diarrhoea 24 out of 62 patients had reduced WBR-50 values. Four of the patients with low WBR-50 and one in the group with normal WBR-50 had previously been cholecystectomized. In a consecutive study, 15 patients were investigated before and after cholecystectomy. In 12, WBR-50 decreased after the operation (p less than 0.05). The results demonstrate the impact of cholecystectomy on the interpretation of the SeHCAT retention results. The results may also add to the understanding of diarrhoea secondary to cholecystectomy.
硒-同型鹅去氧胆酸（SeHCAT）是一种γ标记的合成胆汁酸，适用于胆汁酸吸收不良的体外测量和检测。在本研究中，对138名受试者进行了硒-同型鹅去氧胆酸（75SeHCAT）检测。通过计算48小时内同位素（WBR-50）的生物半衰期对该技术进行了改进。所有回盲部切除的患者WBR-50值均降低，大多数（12例中的8例）累及小肠的克罗恩病患者也是如此。在慢性腹泻患者中，62例患者中有24例WBR-50值降低。WBR-50值低的患者中有4例以及WBR-50值正常组中有1例此前接受过胆囊切除术。在一项连续性研究中，对15例患者在胆囊切除术前和术后进行了检测。其中12例患者术后WBR-50降低（p<0.05）。结果表明胆囊切除术对硒-同型鹅去氧胆酸（SeHCAT）潴留检测结果的解读有影响。这些结果也可能有助于加深对胆囊切除术后继发性腹泻的理解。
