Department of Medical Biochemistry, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University (Ayder Campus), Mekelle, Ethiopia.
Department of Nephrology, Kidney Care, Tiruchirappalli, India.
Cell Biochem Funct. 2020 Dec;38(8):990-1005. doi: 10.1002/cbf.3555. Epub 2020 Jun 4.
MicroRNAs (miRNAs) are 22 nucleotides short, non-coding and tissue-specific single-stranded RNA which modulates target gene expression. Presently, shreds of evidence confirmed that miRNAs play a key role in kidney pathophysiology. The objectives of the present review are to summarize new research data towards the latest developments in the potential use of miRNAs as a diagnostic biomarker for kidney diseases. This holistic information will update the existing knowledge of kidney disease biomarkers. "miRNA profile for Diabetic Kidney disease, Acute kidney injury, Renal fibrosis, hemodialysis, transplants, FSGS, IgAN, etc." are the search keywords which have been used in this review. The search outcome gave an exciting insightful perception of miRNAs competence as a biomarker. Also it is observed that various samples as plasma, urine and biopsies were used for profiling the miRNA expression. The miRNAs were not only used for diagnostic biomarkers but also for therapeutic targets. Each kidney disease showed different miRNAs expression profile and few miRNAs quite common with some kidney diseases. miRNAs are simple and efficient diagnostic biomarkers for kidney diseases.
微小 RNA（miRNAs）是 22 个核苷酸长的、非编码的、组织特异性的单链 RNA，可调节靶基因的表达。目前，有大量证据证实 miRNAs 在肾脏病理生理学中发挥着关键作用。本综述的目的是总结 miRNA 作为肾脏疾病诊断生物标志物的最新研究数据，为其潜在应用提供最新进展。这些全面的信息将更新现有的肾脏疾病生物标志物知识。“糖尿病肾病、急性肾损伤、肾纤维化、血液透析、移植、FSGS、IgAN 等的 miRNA 谱”是本综述中使用的搜索关键字。搜索结果令人兴奋地洞察了 miRNAs 作为生物标志物的能力。此外，还观察到各种样本，如血浆、尿液和活检，用于 miRNA 表达谱分析。miRNAs 不仅被用作诊断生物标志物，也被用作治疗靶点。每种肾脏疾病都显示出不同的 miRNA 表达谱，少数 miRNA 与某些肾脏疾病相当常见。miRNAs 是肾脏疾病的简单而有效的诊断生物标志物。
