Department of Nephrology, The Second Xiangya Hospital at Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
Department of Nephrology, The Second Xiangya Hospital at Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China.
Pharmacol Ther. 2024 Oct;262:108709. doi: 10.1016/j.pharmthera.2024.108709. Epub 2024 Aug 22.
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression by inhibiting the translation of their specific target messenger RNAs. To date, numerous studies have demonstrated changes in the expression of miRNAs in the kidneys throughout the progression of both acute kidney injury (AKI) and chronic kidney disease (CKD) in both human patients and experimental models. The role of specific microRNAs in the pathogenesis of kidney diseases has also been demonstrated. Further studies have elucidated the regulation of these microRNAs in diseased kidneys. Besides, certain miRNAs are detected in plasma and/or urine in kidney diseases and are potential diagnostic biomarkers. In this review, we provide an overview of recent developments in our understanding of how miRNAs contribute to kidney diseases. We also explore the potential of miRNAs as both biomarkers and therapeutic targets for these conditions, and highlight future research directions.
微小 RNA（miRNA）是一类小的非编码 RNA 分子，通过抑制其特定靶信使 RNA 的翻译，在调节基因表达方面发挥着关键作用。迄今为止，大量研究表明，在人类患者和实验模型中，急性肾损伤（AKI）和慢性肾脏病（CKD）的进展过程中，miRNA 在肾脏中的表达发生了变化。特定 microRNA 在肾脏疾病发病机制中的作用也已得到证实。进一步的研究阐明了这些 microRNA 在病变肾脏中的调节。此外，某些 miRNA 在肾脏疾病的血浆和/或尿液中被检测到，是潜在的诊断生物标志物。在这篇综述中，我们概述了最近在理解 miRNA 如何导致肾脏疾病方面的进展。我们还探讨了 miRNA 作为这些疾病的生物标志物和治疗靶点的潜力，并强调了未来的研究方向。
