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成人完全综合征及阈下注意缺陷多动障碍的认知与电生理标志物

Cognitive and electrophysiological markers of adult full syndrome and subthreshold attention-deficit/hyperactivity disorder.

作者信息

Schneidt Alexander, Höhnle Nina Maria, Schönenberg Michael

机构信息

Department of Clinical Psychology and Psychotherapy, University of Tübingen, Germany.

Department of Clinical Psychology and Psychotherapy, University of Tübingen, Germany.

出版信息

J Psychiatr Res. 2020 Aug;127:80-86. doi: 10.1016/j.jpsychires.2020.05.004. Epub 2020 May 15.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) has been often referred to as an executive function deficit disorder with a specific electrophysiological signature. Although previous research suggests that individuals with subthreshold symptoms also suffer from severe impairments in daily life, only few studies have investigated cognitive and neural alterations in this group. Here, we explored impairments in executive functions and their electrophysiological correlates in a sample of adults with full syndrome (N = 113) and subthreshold (N = 46) ADHD compared to controls (N = 42). Results suggest that adults with full syndrome ADHD exhibit more executive function deficits than controls, while there were no electrophysiological differences found between groups. Also, we observed only small differences in neuropsychological variables between subthreshold ADHD and controls and no evidence for altered neural activity in the resting state. While subthreshold ADHD was not associated with altered executive functions or abnormal electrophysiological activity, this group reported significant psychological impairments and comorbidity.

摘要

注意力缺陷多动障碍(ADHD)常被认为是一种具有特定电生理特征的执行功能缺陷障碍。尽管先前的研究表明,有阈下症状的个体在日常生活中也存在严重损害,但只有少数研究调查了该群体的认知和神经改变。在此,我们比较了113名患有完全综合征ADHD的成年人、46名患有阈下ADHD的成年人以及42名对照组成年人在执行功能方面的损害及其电生理相关性。结果表明,患有完全综合征ADHD的成年人比对照组表现出更多的执行功能缺陷,而两组之间未发现电生理差异。此外,我们仅观察到阈下ADHD组与对照组在神经心理学变量上存在微小差异,且没有证据表明静息状态下神经活动发生改变。虽然阈下ADHD与执行功能改变或异常电生理活动无关,但该群体报告了显著的心理损害和共病情况。

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