Department of Botany and Microbiology, Faculty of Science, Alexandria University, Egypt.
Department of Botany and Microbiology, Faculty of Science, Alexandria University, Egypt.
Med Hypotheses. 2020 Oct;143:109904. doi: 10.1016/j.mehy.2020.109904. Epub 2020 May 30.
Coronavirus disease (COVID-19) is caused by SARS-COV2 and has resulted in more than four million cases globally and the death cases exceeded 300,000. Normally, a range of surviving and propagating host factors must be employed for the completion of the infectious process including RPs. Viral protein biosynthesis involves the interaction of numerous RPs with viral mRNA, proteins which are necessary for viruses replication regulation and infection inside the host cells. Most of these interactions are crucial for virus activation and accumulation. However, only small percentage of these proteins is specifically responsible for host cells protection by triggering the immune pathway against virus. This research proposes RPs extracted from bacillus sp. and yeast as new forum for the advancement of antiviral therapy. Hitherto, antiviral therapy with RPs-involving viral infection has not been widely investigated as critical targets. Also, exploring antiviral strategy based on RPs could be a promising guide for more potential therapeutics.
冠状病毒病（COVID-19）由 SARS-COV2 引起，已在全球导致超过 400 万例病例，死亡病例超过 30 万。通常，一系列存活和繁殖的宿主因素必须用于完成感染过程，包括 RPs。病毒蛋白的生物合成涉及许多 RPs 与病毒 mRNA 的相互作用，这些蛋白质对于病毒复制的调节和感染宿主细胞是必要的。这些相互作用中的大多数对于病毒的激活和积累至关重要。然而，这些蛋白质中只有一小部分专门负责通过触发针对病毒的免疫途径来保护宿主细胞。这项研究提出从芽孢杆菌和酵母中提取的 RPs 作为抗病毒治疗的新领域。迄今为止，基于 RPs 的抗病毒治疗作为关键靶点尚未得到广泛研究。此外，基于 RPs 探索抗病毒策略可能为更多潜在的治疗方法提供有希望的指导。
