Minervini Angela, Coccaro Nicoletta, Anelli Luisa, Zagaria Antonella, Specchia Giorgina, Albano Francesco
Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, Italy.
Cancers (Basel). 2020 Jun 3;12(6):1456. doi: 10.3390/cancers12061456.
The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as "architectural transcriptional factors". By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulating gene expression by either enhancing or suppressing the binding of the more usual transcriptional activators and repressors, although they do not themselves have any transcriptional activity. Their involvement in both benign and malignant neoplasias is well-known and supported by a large volume of studies. In this review, we focus on the role of the HMGA proteins in hematological malignancies, exploring the mechanisms through which they enhance neoplastic transformation and how this knowledge could be exploited to devise tailored therapeutic strategies.
高迁移率族AT-钩（HMGA）蛋白是一类非组蛋白染色质重塑蛋白，被称为“结构转录因子”。通过结合富含AT的DNA序列的小沟，它们与转录装置相互作用，改变染色质结构并通过增强或抑制更常见的转录激活因子和抑制因子的结合来调节基因表达，尽管它们本身没有任何转录活性。它们参与良性和恶性肿瘤形成已广为人知，并得到大量研究的支持。在本综述中，我们聚焦于HMGA蛋白在血液系统恶性肿瘤中的作用，探讨它们促进肿瘤转化的机制以及如何利用这些知识制定量身定制的治疗策略。
