Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Radiology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Int J Environ Res Public Health. 2020 Jun 3;17(11):3975. doi: 10.3390/ijerph17113975.
(1) : Due to inconsistencies in epidemiological findings, there has been uncertainty regarding the association of lead compounds with brain tumors. We performed a meta-analysis of published case-control and cohort studies exploring lead compound exposure and brain tumor risk. (2) : We searched PubMed, Embase, and Cochrane to find eligible studies. Eighteen studies were selected for assessment of occupational exposure to lead compound and brain tumor. Pooled estimates of odds ratios (ORs) were obtained using random effects models. We assessed the differences through subgroup analysis according to tumor type, study design, measurements of exposure, and tumor outcome. Statistical tests for publication bias, heterogeneity, and sensitivity analysis were applied. (3) : Our systematic review and meta-analysis showed a not significant association with lead exposure and risk of benign and malignant brain tumors (pooled OR = 1.11, 95% Confidence Interval (CI): 0.95-1.29). Including only malignant brain tumors, the risk of brain tumor was significantly increased (pooled OR = 1.13, 95% CI: 1.04-1.24). (4) : This meta-analysis provides suggestive evidence for an association between lead compound exposure and brain tumor. In future studies, it will be necessary to identify the effect of lead compounds according to the types of brain tumor.
(1)：由于流行病学研究结果的不一致性，关于铅化合物与脑肿瘤之间的关联一直存在不确定性。我们对已发表的病例对照和队列研究进行了荟萃分析，以探讨铅化合物暴露与脑肿瘤风险之间的关系。
(2)：我们在 PubMed、Embase 和 Cochrane 中进行了检索，以找到符合条件的研究。有 18 项研究被纳入评估职业性铅化合物暴露与脑肿瘤的风险。使用随机效应模型获得了比值比（OR）的汇总估计值。我们根据肿瘤类型、研究设计、暴露测量和肿瘤结局进行了亚组分析来评估差异。还应用了发表偏倚、异质性和敏感性分析的统计检验。
(3)：我们的系统评价和荟萃分析显示，铅暴露与良性和恶性脑肿瘤的风险之间无显著关联（汇总 OR = 1.11，95%置信区间（CI）：0.95-1.29）。仅包括恶性脑肿瘤时，脑肿瘤的风险显著增加（汇总 OR = 1.13，95% CI：1.04-1.24）。
(4)：这项荟萃分析提供了铅化合物暴露与脑肿瘤之间存在关联的提示性证据。在未来的研究中，有必要根据脑肿瘤的类型来确定铅化合物的作用。
