接触铅会增加患脑膜瘤和脑癌的风险：一项荟萃分析。

Exposure to lead increases the risk of meningioma and brain cancer: A meta-analysis.

机构信息

School of Medicine, College of Arts & Science of Jianghan University, Wuhan 430000, China.

School of Health Sciences, Wuhan University, Wuhan 430071, China.

出版信息

J Trace Elem Med Biol. 2020 Jul;60:126474. doi: 10.1016/j.jtemb.2020.126474. Epub 2020 Feb 27.

DOI:10.1016/j.jtemb.2020.126474

PMID:32146339

Abstract

OBJECTIVE

To analyze the relationship between environmental lead exposure and various types of brain tumors.

METHODS

Search databases PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure (CNKI) as of July 1, 2019. Stata 15.0 software was used for analysis.

RESULTS

In the case control, lead exposure was associated with gliomas and meningiomas 0.82 (95 % CI: 0.69, 0.95) and 1.06 (95 % CI: 0.65, 1.46). In the cohort study, lead exposure was associated with brain cancer and meningiomas 1.07 (95 % CI: 0.95, 1.19) and 1.06 (95 % CI: 0.94, 1.17). The risk of childhood brain tumors associated with parental lead exposure was 1.17 (95 % CI: 0.99, 1.34).

CONCLUSIONS

Lead may be a risk factor for meningiomas and brain cancers. However, the glioma results suggest that lead may be a protective factor, which needs to be further studied.

摘要

目的

分析环境铅暴露与各种类型脑肿瘤之间的关系。

方法

检索数据库 PubMed、Web of Science、Embase 和中国国家知识基础设施（CNKI），截至 2019 年 7 月 1 日。使用 Stata 15.0 软件进行分析。

结果

在病例对照研究中，铅暴露与胶质瘤和脑膜瘤相关，比值比（OR）分别为 0.82（95%置信区间（CI）：0.69，0.95）和 1.06（95%CI：0.65，1.46）。在队列研究中，铅暴露与脑癌和脑膜瘤相关，OR 分别为 1.07（95%CI：0.95，1.19）和 1.06（95%CI：0.94，1.17）。父母铅暴露与儿童脑肿瘤的风险比（RR）为 1.17（95%CI：0.99，1.34）。