Division of Internal Medicine for the elderly, Trois-Chêne, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Division of Cardiology, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
BMC Geriatr. 2020 Jun 5;20(1):197. doi: 10.1186/s12877-020-01596-7.
High-intensity interval training (HIIT) has been shown to be more effective than moderate-intensity continuous training (MICT) for the physical rehabilitation. However, data on its suitability for older hospitalized patients is scarce.
Randomized controlled trial in a hospital setting. Inclusion of 100 patients, ≥65 years old, hospitalized for rehabilitation after an acute medical condition, in a two-week rehabilitation program of either four HIIT or three MICT sessions per week. Completion was defined as participation in all but two planned sessions accomplishing ≥50% of each session. We assessed: upper-limb muscle strength (handgrip isometric strength test), lower-limb muscle strength (quadriceps and ankle flexion and extension tests); gait speed and spatio-temporal parameters (instrumented walkway), and exercise capacity (6-min walk test). All adverse events were recorded as safety endpoints.
An intention-to-treat analysis showed a 44% completion rate for the HIIT group (95% CI, 30-59) and 77% for MICT (95% CI, 55-82). A modified intention-to-treat analysis restricted to patients who participated in ≥1 session showed an 88% completion rate in the HIIT group (95%CI, 69-97) and an 80% completion rate in MICT (95%CI, 65-90). The exercises most frequently undertaken were the pedal exerciser (54%) and the NuStep (32%). There were no significant differences in the various measures. No serious adverse events occurred.
A HIIT rehabilitation program for this population was feasible, safe and had a high adherence rate.
Clinicatrials.gov ID: NCT02318459. Trial registration date: November 7th, 2014. Retrospectively registered. This study adheres to the CONSORT guidelines.
高强度间歇训练（HIIT）已被证明比中等强度持续训练（MICT）更能促进身体康复。然而，关于其对老年住院患者是否适用的数据却很少。
在医院环境中进行的随机对照试验。纳入 100 名年龄≥65 岁、因急性疾病住院接受康复治疗的患者，参加为期两周的康复计划，每周进行 4 次 HIIT 或 3 次 MICT。完成定义为参加所有计划的 98%以上的课程，即除了两次计划课程外，还参加了≥50%的课程。我们评估了：上肢肌肉力量（握力等长力量测试）、下肢肌肉力量（股四头肌和踝关节屈伸测试）；步态速度和时空参数（仪器步态测试）以及运动能力（6 分钟步行测试）。所有不良事件均作为安全性终点进行记录。
意向治疗分析显示，HIIT 组的完成率为 44%（95%CI，30-59），MICT 组的完成率为 77%（95%CI，55-82）。一项针对至少参加 1 次课程的患者的改良意向治疗分析显示，HIIT 组的完成率为 88%（95%CI，69-97），MICT 组的完成率为 80%（95%CI，65-90）。最常进行的运动是脚踏车（54%）和 NuStep（32%）。各项指标均无显著差异。没有发生严重不良事件。
该人群的 HIIT 康复计划是可行的、安全的，且依从性高。
ClinicalTrials.gov 注册号：NCT02318459。试验注册日期：2014 年 11 月 7 日。回顾性注册。本研究符合 CONSORT 指南。
