概念化脊椎动物甾醇组。
Conceptualizing the Vertebrate Sterolbiome.
机构信息
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA
出版信息
Appl Environ Microbiol. 2020 Aug 3;86(16). doi: 10.1128/AEM.00641-20.
Abstract
Vertebrates synthesize a diverse set of steroids and bile acids that undergo bacterial biotransformations. The endocrine literature has principally focused on the biochemistry and molecular biology of host synthesis and tissue-specific metabolism of steroids. Host-associated microbiota possess a coevolved set of steroid and bile acid modifying enzymes that match the majority of host peripheral biotransformations in addition to unique capabilities. The set of host-associated microbial genes encoding enzymes involved in steroid transformations is known as the sterolbiome. This review focuses on the current knowledge of the sterolbiome as well as its importance in medicine and agriculture.
摘要
脊椎动物合成了一系列多样化的类固醇和胆酸，这些物质会经历细菌生物转化。内分泌学文献主要侧重于宿主合成和类固醇组织特异性代谢的生物化学和分子生物学。与宿主相关的微生物群落拥有一套共同进化的类固醇和胆酸修饰酶，除了独特的能力外，这些酶还能匹配宿主大多数的外围生物转化。与宿主相关的微生物基因编码参与类固醇转化的酶的集合被称为甾醇组。本综述重点介绍了甾醇组的现有知识及其在医学和农业中的重要性。
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