Program for Computational and Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Department of Internal Medicine, Division of Infectious Diseases, The University of Michigan Medical School, Ann Arbor, MI, USA.
Trends Cancer. 2020 Mar;6(3):192-204. doi: 10.1016/j.trecan.2020.01.004. Epub 2020 Feb 7.
The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach.
人体内部和表面的微生物集合体，即人类微生物组，可能会影响癌症的发生、发展以及对治疗的反应，包括癌症免疫疗法。微生物组影响癌症的机制可以产生新的诊断和治疗方法，但仍有许多未知之处。微生物、饮食、宿主因素、药物以及癌症内部细胞-细胞之间的相互作用之间的相互作用可能涉及复杂的反馈，没有单一的组成部分可以解释系统的所有行为。要了解宿主相关微生物群落在癌症系统中的作用，需要采用微生物生态学、免疫学、癌症细胞生物学和计算生物学相结合的多学科方法，即系统生物学方法。
