Department of Ophthalmology, Okan University School of Medicine, İstanbul, Turkey.
Department of Ophthalmology, Kars Harakani State Hospital, Yenişehir Mahallesi, İsmail Aytemiz Blv. No:55, Merkez, 36200, Kars, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2020 Sep;258(9):1959-1963. doi: 10.1007/s00417-020-04777-7. Epub 2020 Jun 6.
Coronavirus disease 2019 (COVID-19) is an ongoing global public health problem, and most of the COVID-19 research is focused mainly on the respiratory system because of life-threatening results. However, manifestations in other organs should not be ignored since they can also be a mode of transmission. We sought to describe the ocular manifestations of COVID-19 and investigate the association between ocular involvement and clinical presentation and laboratory outcomes.
This cross-sectional study was conducted between March 1, 2020, and April 30, 2020. Ninety-three sequentially hospitalized and clinically confirmed COVID-19 patients were included in the study. The systemic and ocular symptoms, clinical findings, and laboratory outcomes were recorded.
Of the 93 COVID-19 patients, 54 (58.1%) were male, and 39 (41.9%) were female. Mean age of the patients was 39.4 ± 21.9 (min 7, max 88) years. Twenty patients (n 21.5%) had at least one ocular abnormality. Most common findings included hyperemia (n = 20), epiphora (n = 9), increased secretion (n = 6), chemosis (n = 3), follicular conjunctivitis (n = 2), and episcleritis (n = 2). The most common symptom was photophobia (n 15). Patients with ocular involvement were more likely to have higher neutrophil counts (p = 0.001), and increased CRP (p < 0.001), PCT (p = 0.001), and ESR levels (p < 0.001). Mean lymphocyte count was statistically lower in patients with ocular manifestations (p = 0.001). Mean age and number of patients with fever over 37.3 °C in the ocular involvement group was found to be higher (p < 0.001, p = 0.006, respectively).
Older age, high fever, increased neutrophil/lymphocyte ratio, and high levels of acute phase reactants seemed to be risk factors for ocular involvement.
2019 年冠状病毒病（COVID-19）是一个持续存在的全球公共卫生问题，由于危及生命的结果，大多数 COVID-19 研究主要集中在呼吸系统上。然而，由于其他器官的表现也可能成为传播途径，因此不应忽视这些表现。我们旨在描述 COVID-19 的眼部表现，并研究眼部受累与临床表现和实验室结果之间的关联。
本横断面研究于 2020 年 3 月 1 日至 4 月 30 日进行。共纳入 93 例连续住院且临床确诊的 COVID-19 患者。记录全身和眼部症状、临床发现和实验室结果。
93 例 COVID-19 患者中，男性 54 例（58.1%），女性 39 例（41.9%）。患者平均年龄为 39.4 ± 21.9（最小 7 岁，最大 88 岁）岁。20 例（21.5%）患者至少有一种眼部异常。最常见的发现包括充血（n = 20）、溢泪（n = 9）、分泌物增加（n = 6）、球结膜水肿（n = 3）、滤泡性结膜炎（n = 2）和表层巩膜炎（n = 2）。最常见的症状是畏光（n = 15）。眼部受累的患者更有可能出现中性粒细胞计数升高（p = 0.001）、CRP（p < 0.001）、PCT（p = 0.001）和 ESR 水平升高（p < 0.001）。眼部表现患者的平均淋巴细胞计数明显较低（p = 0.001）。在眼部受累组中，年龄较大和发热超过 37.3°C 的患者人数更多（p < 0.001，p = 0.006）。
年龄较大、高热、中性粒细胞/淋巴细胞比值升高以及急性期反应物水平升高似乎是眼部受累的危险因素。
