Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni Suef, 62511, Egypt.
Department of Pathology, Era's Medical College, Era University, Lucknow, UP, India.
Inflammopharmacology. 2020 Dec;28(6):1525-1536. doi: 10.1007/s10787-020-00723-5. Epub 2020 Jun 5.
The atypical adenomatous hyperplasia (AAH) is invariably an incidental histological change, with no clinical findings specific for its diagnosis, and the mean patient age at diagnosis is 64-70 years. The incidence of AAH varies between 1.5 and 19.6% of transurethral resections and in up to 33% of radical prostatectomies. Herbal medicines are becoming a popular option in the treatment of prostatic-related diseases, such as date palm pollen and saw palmetto in the treatment of prostatic hyperplasia. A testosterone/citral-induced AAH in Wistar rat model was used to evaluate the protective effect of Sophora japonica fruit extract (SFE). The present study suggests that SFE has an ameliorating effect on the prostatic hypertrophy and inflammation through its effect on clusterin, IGF, IL-6, IL-8, TNF-α, and TGF-β1 expression. In addition, the administration of SFE ameliorated the inflammatory score, and histopathological changes in AAH-induced rats in a dose-dependent manner. The treatment with SFE reduced the number of prostatic acini in AAH rat model and decreased the production of pro-inflammatory cytokines. The fruit extract of S. japonica was characterized by determination total phenol content (60.3 mg of gallic acid equivalent/g of dry extract), total flavonoid content (97.9 mg quercetin equivalent/g of dry extract) and the major isoflavonoid sophoricoside (302.9 ± 2.6 µg/g of the extract). In conclusion, SFE has an ameliorating effect on the prostatic hypertrophy and inflammation. This effect may be attributed to the ability of SFE to decrease the production of pro-inflammatory cytokines, TNF-α, IL-1β and IGF-1 as well as an increase in TGF-β1.
不典型腺瘤样增生（AAH）始终是一种偶然的组织学变化，没有特定的临床发现可以诊断，诊断时患者的平均年龄为 64-70 岁。AAH 的发生率在经尿道切除术为 1.5-19.6%之间，在根治性前列腺切除术中高达 33%。草药在前列腺相关疾病的治疗中变得越来越受欢迎，如棕榈花粉和锯棕榈治疗前列腺增生。本研究采用睾酮/柠檬醛诱导的 Wistar 大鼠模型来评估苦参果提取物（SFE）的保护作用。本研究表明，SFE 通过对 clusterin、IGF、IL-6、IL-8、TNF-α 和 TGF-β1 表达的影响，对前列腺肥大和炎症具有改善作用。此外，SFE 以剂量依赖的方式改善了 AAH 诱导大鼠的炎症评分和组织病理学变化。SFE 治疗可减少 AAH 大鼠模型中前列腺腺泡的数量，并减少促炎细胞因子的产生。苦参果提取物的总酚含量（60.3mg 没食子酸当量/g 干提取物）、总黄酮含量（97.9mg 槲皮素当量/g 干提取物）和主要异黄酮槐定碱（302.9±2.6µg/g 提取物）均已确定。总之，SFE 对前列腺肥大和炎症具有改善作用。这种作用可能归因于 SFE 降低促炎细胞因子 TNF-α、IL-1β 和 IGF-1 的产生以及 TGF-β1 的增加。
