Molecular Pathology and Cytogenetics Division, Department of Pathology, Children's Medical Center, Tehran University of Medical Sciences, No 63, Gharib Ave, Keshavarz Blv, Tehran, 1419733151, Iran.
Department of Infectious Diseases, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Head Neck Pathol. 2021 Mar;15(1):352-360. doi: 10.1007/s12105-020-01183-7. Epub 2020 Jun 5.
Rosai-Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.
罗-道二氏病（RDD）是一种罕见的自限性疾病，最常见于年轻患者，表现为巨大的、无痛的颈淋巴结病。也可能发生结外累及。组织病理学评估是主要的诊断方式。我们报告了一例不常见的 RDD 病例，表现为颈淋巴结病和偶然发现的鼻窦肿块，临床上令人担忧为恶性肿瘤。我们强调，高度的临床怀疑对于准确诊断 RDD 至关重要。临床医生和病理学家应在颈淋巴结病的鉴别诊断中考虑 RDD，特别是在年轻患者中。
