Nackeeran Sirpi, Katz Jonathan, Ramasamy Ranjith, Marcovich Robert
Department of Urology, University of Miami, Miami, FL, USA.
World J Urol. 2021 Apr;39(4):1269-1275. doi: 10.1007/s00345-020-03286-w. Epub 2020 Jun 5.
Increasing age, male gender, and metabolic syndrome are associated with kidney stone formation. As sex hormones change with age, gender, and metabolic syndrome, we hypothesized that sex hormones may underlie the physiologic changes affecting stone formation.
We analyzed the relationships between testosterone, estradiol, and history of kidney stones using data from 10,193 participants in the Continuous National Health and Nutrition Examination Survey (NHANES) database from 2013-2016. We performed logistic regression analysis to analyze the predictive value of low testosterone and low estradiol on the history of kidney stones in both males and females. Self-reported history of kidney stone diagnosis was the outcome.
After adjusting for risk factors known to be associated with nephrolithiasis such as age, race, BMI, and medical comorbidities including: gout, angina, coronary disease, stroke, asthma, hypertension, and diabetes, multiple regression analysis demonstrated that there is no independent association between sex hormones (testosterone and estradiol) and history of kidney stones in either males or females.
There appears to be no association between sex hormones and history of kidney stones. Whether there is a more complex interaction of sex hormone levels and the shared association with factors such as metabolic syndrome requires additional investigation. Further studies matching menopausal status for women are necessary to further investigate the potential relationship between estrogen and kidney stones.
年龄增长、男性性别以及代谢综合征与肾结石形成有关。由于性激素会随年龄、性别和代谢综合征而变化，我们推测性激素可能是影响结石形成的生理变化的基础。
我们使用来自2013 - 2016年美国国家健康与营养检查连续调查（NHANES）数据库中10193名参与者的数据，分析了睾酮、雌二醇与肾结石病史之间的关系。我们进行了逻辑回归分析，以分析低睾酮和低雌二醇对男性和女性肾结石病史的预测价值。自我报告的肾结石诊断病史为研究结果。
在对已知与肾结石相关的风险因素进行调整后，如年龄、种族、体重指数以及包括痛风、心绞痛、冠状动脉疾病、中风、哮喘、高血压和糖尿病等在内的合并症，多元回归分析表明，无论是男性还是女性，性激素（睾酮和雌二醇）与肾结石病史之间均无独立关联。
性激素与肾结石病史之间似乎没有关联。性激素水平与诸如代谢综合征等因素之间是否存在更复杂的相互作用，还需要进一步研究。对女性绝经状态进行匹配的进一步研究对于深入探究雌激素与肾结石之间的潜在关系是必要的。
