Phytomedicine, Biochemical Toxicology and Biotechnology Laboratory, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.
Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, 3886, South Africa.
J Endocrinol Invest. 2021 Feb;44(2):265-276. doi: 10.1007/s40618-020-01280-y. Epub 2020 Jun 5.
In this study, antihyperglycaemic and level of gene expression of glucose transporters in alloxan-induced diabetic rats administered aqueous extract of S. macrocarpon leaves were assessed.
Diabetes was induced by a single intraperitoneal (I.P) injection of freshly prepared alloxan. The animals were divided into six groups, euthanized on the fourteenth day of the experiment and different hyperglycaemic parameters were evaluated. Administration of different doses of the plant extract significantly (p < 0.05) reduced the fasting blood glucose level, glycated haemoglobin, serum lipid profiles, lipid peroxidation, and glucose-6-phosphatase. There was a significant (p < 0.05) increase in liver glycogen content, antioxidant enzyme activities, hexokinase activity, and expression of glucose transporter genes (GLUT-2 and GLUT-4) in diabetic rats administered different doses of S. macrocarpon.
It can be concluded that the aqueous extract of S. macrocarpon leaves could be helpful in the management of diabetes mellitus and its metabolic complications.
本研究评估了给予匙羹藤叶水提物对链脲佐菌素诱导的糖尿病大鼠的降血糖作用和葡萄糖转运体基因表达水平。
糖尿病通过单次腹腔内（I.P.）注射新鲜制备的链脲佐菌素诱导。动物被分为六组，在实验的第 14 天处死，并评估不同的高血糖参数。给予不同剂量的植物提取物可显著（p<0.05）降低空腹血糖水平、糖化血红蛋白、血清脂质谱、脂质过氧化和葡萄糖-6-磷酸酶。糖尿病大鼠给予不同剂量匙羹藤提取物后，肝糖原含量、抗氧化酶活性、己糖激酶活性和葡萄糖转运体基因（GLUT-2 和 GLUT-4）的表达均显著增加（p<0.05）。
可以得出结论，匙羹藤叶的水提物可能有助于糖尿病及其代谢并发症的管理。
