Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
J Pharm Biomed Anal. 2020 Sep 5;188:113393. doi: 10.1016/j.jpba.2020.113393. Epub 2020 May 28.
Electrochemical sensors have shown great appeal for the simultaneous analysis of pharmaceutical compounds. In this way, the presence study described first electroanalytical sensor for simultaneous determination of adrenalone and folic acid. The two-amplified voltammetric sensor was developed by modifying carbon paste electrode (CPE) with NiO/SWCNTs composite and 1-butyl-3-methylimidazolium methanesulfonate (1B3MIMS) and used for simultaneous determination of adrenalone and folic acid. The NiO/SWCNTs was synthesised by a fast and low-cost precipitation strategy and then characterised by EDS, FESEM and XRD methods. The results confirmed a particle size range of ⁓ 26.93-33.87 nm for NiO nanoparticle decorated at SWCNTs. The cyclic voltammetric investigation showed that oxidation potentials of adrenalone and folic acid depend on changing the pH value. The maximum oxidation current for the simultaneous analysis of two compounds occurred at pH = 7.0. In this condition, the sensor showed linear dynamic range 0.01-400 μM and 0.3-350 μM for determination of adrenalone and folic acid, respectively. The NiO/SWCNTs/1B3MIMS/CPE was then used as an ultrasensitive electroanalytical sensor for determination of adrenalone and folic acid in injection samples with recovery ratio between 98.2-103.66 %.
电化学传感器在同时分析药物化合物方面表现出了极大的吸引力。在这种情况下，本文首次描述了一种用于同时测定肾上腺素和叶酸的电分析传感器。该双扩增伏安传感器是通过在碳糊电极（CPE）上修饰 NiO/SWCNTs 复合材料和 1-丁基-3-甲基咪唑𬭩甲烷磺酸盐（1B3MIMS）来制备的，并用于同时测定肾上腺素和叶酸。NiO/SWCNTs 通过快速且低成本的沉淀策略合成，并通过 EDS、FESEM 和 XRD 方法进行了表征。结果证实，NiO 纳米颗粒在 SWCNTs 上的粒径范围为 ⁓ 26.93-33.87nm。循环伏安研究表明，肾上腺素和叶酸的氧化电位取决于 pH 值的变化。同时分析两种化合物的最大氧化电流出现在 pH=7.0 时。在这种条件下，传感器对肾上腺素和叶酸的线性动态范围分别为 0.01-400 μM 和 0.3-350 μM。然后，将 NiO/SWCNTs/1B3MIMS/CPE 用作超灵敏电分析传感器，用于测定注射液中的肾上腺素和叶酸，回收率在 98.2-103.66%之间。
