Department of Biology, Jeju National University, Jeju, 63243, South Korea.
Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, 04401, South Korea.
Ecotoxicol Environ Saf. 2020 Sep 15;201:110796. doi: 10.1016/j.ecoenv.2020.110796. Epub 2020 Jun 3.
1,2-Hexanediol is commonly used in the cosmetic industry as a preservative, an emollient, and a moisturizing agent. However, studies on the scientific toxicity of 1,2-hexanediol are limited. In this study, we evaluated the potential toxic effects of 1,2-hexanediol using phytotoxicity and cytotoxicity testing methods. Phytotoxicity tests using Brassica campestris subsp. napus and Latuca sativa L. showed that 1,2-hexanediol significantly inhibited seed germination and root elongation at the lowest concentration (0.1%). Additionally, plants treated with 1,2-hexanediol failed to survive. In cytotoxicity tests, RAW 264.7 and HK-2 cells treated with 1.0% 1,2-Hexanediol showed a significant decline in viability, followed by death. Since most personal care products contain >2% 1,2-hexanediol, it is highly likely that 1,2-hexanediol is toxic to humans. Moreover, if 1,2-hexanediol enters the human body either via oral intake or through an open wound, it could have critical effects. Furthermore, upon release into the environment, 1,2-hexanediol could cause considerable damage to plants and other organisms. Therefore, further investigation of 1,2-hexanediol is required to prevent toxicity to humans and other living organisms.
1,2-己二醇在化妆品行业中通常用作防腐剂、润肤剂和保湿剂。然而，关于 1,2-己二醇的科学毒性研究有限。在这项研究中，我们使用植物毒性和细胞毒性测试方法评估了 1,2-己二醇的潜在毒性作用。使用 Brassica campestris subsp. napus 和 Latuca sativa L.进行的植物毒性测试表明，1,2-己二醇在最低浓度（0.1%）下显著抑制种子发芽和根伸长。此外，用 1,2-己二醇处理的植物无法存活。在细胞毒性测试中，用 1.0% 1,2-己二醇处理的 RAW 264.7 和 HK-2 细胞的活力显著下降，随后死亡。由于大多数个人护理产品中含有>2%的 1,2-己二醇，因此 1,2-己二醇对人类很可能具有毒性。此外，如果 1,2-己二醇通过口服摄入或通过开放性伤口进入人体，它可能会产生严重影响。此外，1,2-己二醇释放到环境中后，可能会对植物和其他生物体造成相当大的损害。因此，需要进一步研究 1,2-己二醇，以防止对人类和其他生物体的毒性。
