Nikezić Ana V Vujačić, Bondžić Aleksandra M, Vasić Vesna M
Department of Physical Chemistry, VINČA Institute of Nuclear Sciences - National Institute of th Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Department of Physical Chemistry, VINČA Institute of Nuclear Sciences - National Institute of th Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Eur J Pharm Sci. 2020 Aug 1;151:105412. doi: 10.1016/j.ejps.2020.105412. Epub 2020 Jun 4.
A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.
一种基于纳米颗粒及相关纳米结构的新型药物设计方法，用于实现有效的药物递送，在未来医学治疗中，尤其是癌症治疗方面具有极其重要的意义。纳米材料在提高药物递送效率方面具有巨大潜力，且具有高度的生物相容性。此外，对于生物医学应用而言，它们必须是可生物降解的，具有延长的循环半衰期，不易聚集或在体内引发炎症反应，并且具有成本效益。此类结构的功效高度依赖于其化学性质以及形状、电荷、尺寸、表面修饰和负载方法。在此，我们着重探讨使用负载各种药物的不同种类纳米颗粒及类似纳米结构以实现特定靶向和可控药物释放的潜力。因此，基于纳米颗粒的药物递送的计算建模有助于更好地理解递送系统的各个部分。本综述着重介绍了各种类型纳米颗粒及类似纳米结构在药物递送应用方面的最新进展，旨在对毒性更低、效果更优的治疗方法进行批判性综述。
