Salami Monsurah Olabimpe, Aribaba Olufisayo Temitayo, Musa Kareem Olatunbosun, Rotimi-Samuel Adekunle, Onakoya Adeola Olukorede
Hotel Dieu Hospital/Queens University, Kingston, ON, Canada.
Department of Ophthalmology (Guinness Eye Centre), Lagos University Teaching Hospital/College of Medicine of the University of Lagos, Idi-Araba, Lagos, Nigeria.
Int Ophthalmol. 2020 Oct;40(10):2707-2716. doi: 10.1007/s10792-020-01456-8. Epub 2020 Jun 6.
To determine the relationship between corneal sensitivity and diabetic retinopathy among diabetics attending Lagos University Teaching Hospital, compared to their age-sex-matched non-diabetics, with a view to proposing its use as a screening tool for diabetic retinopathy.
The study was a hospital-based comparative cross-sectional study among diabetics aged 25-65 years and their age-sex-matched non-diabetics at Lagos University Teaching Hospital, Lagos, Nigeria. Interviewer-based questionnaire was administered. Corneal sensitivity was assessed with Cochet-Bonnet aesthesiometer. Dilated fundoscopy examination was carried out using slit-lamp bio-microscope with 78D lens and binocular indirect ophthalmoscope.
A total of 120 diabetics and 120 age- and sex-matched non-diabetics were enrolled into the study. Among the diabetics, the mean corneal sensitivity was 52.6 ± 6.9 mm, which was statistically lower than among non-diabetics - 58.2 ± 3.0 mm (p-value < 0.05). Twenty-one percent of the diabetic respondents had diabetic retinopathy. The mean cornea sensitivity was statistically lower among diabetics who had developed diabetic retinopathy compared to those with no diabetic retinopathy (48.9 ± 7.3 vs. 55.3 ± 5.4, p < 0.05). The sensitivity and specificity of the aesthesiometer for proliferative diabetic retinopathy at 55 mm cut-off were 100% and 58%, respectively.
Cornea sensitivity was significantly lower among diabetics with retinopathy compared to those without retinopathy. Also, the degree of cornea sensation loss among diabetics reduced significantly with severity of diabetic retinopathy. Larger validity studies need to be conducted to further assess the use of corneal aesthesiometer as a screening tool for diabetic retinopathy among non-ophthalmologists and other cadres of health workers.
确定拉各斯大学教学医院的糖尿病患者中角膜敏感性与糖尿病视网膜病变之间的关系，并与年龄和性别匹配的非糖尿病患者进行比较，以期将其用作糖尿病视网膜病变的筛查工具。
该研究是在尼日利亚拉各斯拉各斯大学教学医院对25至65岁的糖尿病患者及其年龄和性别匹配的非糖尿病患者进行的一项基于医院的比较性横断面研究。采用基于访谈者的问卷进行调查。使用科谢-博内眼压计评估角膜敏感性。使用带有78D透镜的裂隙灯生物显微镜和双目间接检眼镜进行散瞳眼底镜检查。
共有120名糖尿病患者和120名年龄和性别匹配的非糖尿病患者纳入研究。糖尿病患者的平均角膜敏感性为52.6±6.9毫米，在统计学上低于非糖尿病患者的58.2±3.0毫米（p值<0.05）。21%的糖尿病受访者患有糖尿病视网膜病变。与没有糖尿病视网膜病变的患者相比，患有糖尿病视网膜病变的糖尿病患者的平均角膜敏感性在统计学上更低（48.9±7.3对55.3±5.4，p<0.05）。在55毫米截断值时，眼压计对增殖性糖尿病视网膜病变的敏感性和特异性分别为100%和58%。
与没有视网膜病变的糖尿病患者相比，患有视网膜病变的糖尿病患者的角膜敏感性显著更低。此外，糖尿病患者的角膜感觉丧失程度随着糖尿病视网膜病变的严重程度而显著降低。需要进行更大规模的有效性研究，以进一步评估角膜眼压计作为非眼科医生和其他卫生工作者群体中糖尿病视网膜病变筛查工具的用途。
